US 7,531,673 B2
	Preparation of amino acid amides
Palle V. R. Acharyulu, Hyderabad (India); and C. M. Haricharan Raju, Hyderabad (India)
Assigned to Dr. Reddy's Laboratories Limited, Hyderabad (India); and Dr. Reddy's Laboratories, Inc., Bridgewater, N.J. (US)
Filed on Feb. 16, 2005, as Appl. No. 11/58,835.
Claims priority of provisional application 60/545428, filed on Feb. 18, 2004.
Prior Publication US 2005/0182262 A1, Aug. 18, 2005
Int. Cl. C07D 207/00 (2006.01)

U.S. Cl. 548—543  [548/550]

5 Claims

1. A process for preparing (−)-(S)-α-ethyl-2-oxo-1-pyrrolidineacetamide, comprising reacting (S)-2-aminobutyramide hydrochloride with a compound having the structure: wherein X is a carboxylic activating group and Y is Cl, Br, I, mesyl, or tosyl in the presence of tetrabutylammonium bromide; adjusting pH to from about 7 to about 7.5; and recovering (−)-(S)-α-ethyl-2-oxo-1-pyrrolidineacetamide.