| US 7,531,604 B2 | ||
| Phospholipid derivative | ||
| Syunsuke Ohhashi, Kanagawa (Japan); Kazuhiro Kubo, Kanagawa (Japan); Chika Itoh, Kanagawa (Japan); Tohru Yasukohchi, Kanagawa (Japan); Hiroshi Kikuchi, Tokyo (Japan); Norio Suzuki, Chiba (Japan); Miho Kurosawa, Shizuoka (Japan); and Hitoshi Yamauchi, Tokyo (Japan) | ||
| Assigned to NOF Corporation, Tokyo (Japan); and Daiichi Pharmaceutical Co., Ltd., Tokyo (Japan) | ||
| Appl. No. 10/529,692 PCT Filed Sep. 30, 2003, PCT No. PCT/JP03/12502 § 371(c)(1), (2), (4) Date Dec. 06, 2005, PCT Pub. No. WO2004/029104, PCT Pub. Date Apr. 08, 2004. |
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| Claims priority of application No. 2002-286306 (JP), filed on Sep. 30, 2002. | ||
| Prior Publication US 2006/0110436 A1, May 25, 2006 | ||
| Int. Cl. C08F 8/32 (2006.01); C08F 8/40 (2006.01); A61K 9/127 (2006.01); A61K 47/32 (2006.01); A61P 35/00 (2006.01) | ||
| U.S. Cl. 525—327.6 [525/329.9; 525/330.5; 525/379; 525/340; 424/450; 424/486; 424/487] | 11 Claims |
| 1. A phospholipid derivative, which is a phospholipid and is a copolymer containing, as essential component units,
(A) a component unit A represented by the following formula (1),
(B) a component unit B represented by the following formula (2A) and/or the following formula (2B), and
(C) a component unit C represented by the following formula (3):
 wherein, in the formula (1), R1 and R2 independently represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO independently represents an oxyalkylene group having
2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented
as 4≤m≤100; and R4 represents hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms or an acyl group having 1 to 20 carbon atoms; in
the formula (2A), X independently represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; and in
the formula (3), R5CO and R6CO independently represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium
or an organic ammonium, and Y represents hydrogen atom, an alkali metal atom ammonium or an organic ammonium, wherein a molar
ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and
the component unit C is contained at a ratio of from 1 to 5 moles per 1 mole of the copolymer.
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