| US 7,531,571 B2 | ||
| Chroman derivatives as estrogenic compounds | ||
| Gerrit Herman Veeneman, Schaijk (Netherlands); and Neeltje Miranda Teerhuis, Wijchen (Netherlands) | ||
| Assigned to N.V. Organon, Oss (Netherlands) | ||
| Filed on Jan. 10, 2006, as Appl. No. 11/328,760. | ||
| Application 11/328760 is a continuation of application No. 10/220509, granted, now 7,214,706, previously published as PCT/EP01/02144, filed on Feb. 26, 2001. | ||
| Claims priority of application No. 00200713 (EP), filed on Mar. 01, 2000. | ||
| Prior Publication US 2006/0160889 A1, Jul. 20, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 31/35 (2006.01); C07D 407/00 (2006.01) | ||
| U.S. Cl. 514—457 [549/399] | 5 Claims |
1. A chroman compound having formula 1
 in which
R1 is (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl, and independently R1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton;
R4 is Hal, CF3, OH or (1C-2C)alkyloxy;
R2, R3, and R5 are independently H, Hal, CF3, (1C-4C)alkyl, (2C-4C)alkenyl, or (2C-4C)alkynyl;
or a prodrug thereof.
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