| 1. A method for ameliorating or treating Cryopyrin-associated Periodic Syndromes, Muckle-Wells Syndrome, Familial Cold Autoinflammatory
Syndrome, Familial Mediterranean Fever, Chronic Infantile Neurological Cutaneous and Articular Syndrome, Neonatal Onset Multisystem
Inflammatory Disease, TNFR1-Associated Periodic Syndrome, Hyper-IgD periodic fever Syndrome, Blau's syndrome, systemic onset
juvenile idiopathic arthritis, or macrophage activation syndrome in a subject, comprising administering a compound or a pharmaceutical
composition comprising said compound to said subject, wherein said compound is
and each stereoisomerthereof, including:
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