R¹ is hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, —OCH₂cycloalkyl, arylalkyl, —COOH or —CONR¹²R¹³;

R² and R³ are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, —CO alkyl, —CO substituted alkyl, —COaryl, —CO substituted aryl, —COarylalkyl, —CO substituted heteroaryl, —CO heterocyclyl alkyl, —CO(CH₂)_nNR⁴R⁵, —CONR⁴R⁵, —CONHSO₂R⁵, —NHCONHR⁵, —(CH₂)_n-aryl, —(CH₂)_n-substituted aryl, —(CH₂)_n-substituted heteroaryl, —(CH₂)₂(CH₂)_n—OH, —(CH₂)₂(CH₂)_n—NH₂, —(CH₂)₂(CH₂)_n—S-alkyl, —SO₂alkyl or —COCF₃, two of which may be attached to the same ring carbon atom; or

R² and R³ are taken together with the nitrogen atom to which they are attached to form an optionally substituted 4-8 membered ring, said ring optionally containing one or more additional heteroatoms selected from —N—, —S— and —O—; said substituents on the rings are independently selected from the group consisting of hydrogen, —OH, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, arylalkyl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyclyl, —CONR⁴R⁵, —OCONR⁴R⁵, —CONHSO₂R⁵, —NHCONR⁴R⁵, —NHCOalkyl, —NHCOsubstituted alkyl, —NHCOalkoxyalkyl, —NHCOalkylCOalkoxy, —NHCO(CH₂)_nN R⁴R⁵, NHCO(CH₂)_nbisphenyl, —NHCOaryl, —NHCOsubstituted aryl, —NHCO arylalkyl, —NHCOsubstituted arylalkyl, —NHCOheteroaryl, —NHCOsubstituted heteroaryl, —NHCOheteroarylalkyl, —NHCOsubstituted heteroarylalkyl, —NHCO(CH₂)_n CN, —NHCOaminosulfonylalkyl, —NHCO(CH₂)_nNH₂, —NHCOCF₃, —NHSO₂R⁴, —CH₂OR⁴, —(CH₂)_n-aryl, —(CH₂)_n-substituted aryl, —(CH₂)_n-substituted heteroaryl, —(CH₂)_n—OH, —(CH₂)_nNH₂, —(CH₂)_nS-alkyl;

R⁴ and R⁵ are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, dihydroxyalkyl, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halogen, cyano, amino or substituted amino;

R⁶ is H, C₁-C₆ alkyl, C₁-C₆ alkenyl, C₁-C₆ alkynyl, C₃-C₈ cycloalkyl, C₁-C₅ arylalkyl, aryl, substituted aryl, heteroarylalkyl, substituted heteroarylalkyl, heteroaryl, substituted heteroaryl or C₄-C₈ heterocyclyl with at least one atom on the ring selected from nitrogen or oxygen atom, and each of said R⁶ groups optionally substituted with 1 to 3 groups selected from the group consisting of —OH, OR⁸, —COOR⁸, —NH₂, —NR⁸R⁹, —CONHR⁸, —OCONHR⁸, —CONHSO₂R⁸, —NHCONHR⁸, —SR⁸, —S(═O)R⁸, —SO₂R⁸ and —SO₂N R⁸R⁹;

R⁸ is C₁-C₆ alkyl, C₃-C₆ cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl group; said substituents on the substituted aryl or substituted heteroaryl group are one or more hydrogen, halogen, alkyl, substituted alkyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxy or substituted aryloxy;

R⁹ is hydrogen, C₁-C₆ alkyl or C₃-C₆ cycloalkyl;

R¹² and R¹³ are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxyalkyl, dihydroxyalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino and substituted amino; or

R¹² and R¹³ are taken together with the nitrogen atom to which they are attached to form an optionally substituted 4-8 membered ring, said ring optionally containing one or more additional heteroatoms selected from —N—, —S— and —O—; said substituents on the ring are independently hydrogen, —OH, alkyl, substituted alkyl or hydroxyalkyl;

n is 0, 1, 2, 3 or 4;

or a pharmaceutically acceptable salt or stereoisomer thereof.