US 7,531,536 B2
Pyrazole compounds useful as protein kinase inhibitors
David Bebbington, Newbury (United Kingdom); Jean-Damien Charrier, Wantage (United Kingdom); Julian Golec, Swindon (United Kingdom); Andrew Miller, Didcot (United Kingdom); and Ronald Knegtel, Abingdon (United Kingdom)
Assigned to Vertex Pharmaceuticals Incorporated, Cambridge, Mass. (US)
Filed on Aug. 01, 2003, as Appl. No. 10/632,428.
Application 10/632428 is a continuation of application No. 10/025164, filed on Dec. 19, 2001, granted, now 6,664,247.
Claims priority of provisional application 60/286949, filed on Apr. 27, 2001.
Claims priority of provisional application 60/257887, filed on Dec. 21, 2000.
Prior Publication US 2005/0038023 A1, Feb. 17, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 403/14 (2006.01); A61K 31/4155 (2006.01)
U.S. Cl. 514—231.8  [514/235.8; 514/252.14; 514/274; 544/122; 544/295; 544/317] 17 Claims
 
1. A compound of formula IIIa:

OG Complex Work Unit Drawing
or a pharmaceutically acceptable salt thereof, wherein:
Rx and Ry are independently selected from T-R3 or L-Z-R3;
R1 is T-(Ring D);
Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, said heteroaryl or heterocyclyl ring having 1-4 ring heteroatoms selected from nitrogen, oxygen or sulfur, wherein each substitutable ring carbon of Ring D is independently substituted by oxo, T-R5, or V-Z-R5, and each substitutable ring nitrogen of Ring D is independently substituted by —R4;
T is a valence bond or a C1-4 alkylidene chain;
Z is a C1-4 alkylidene chain;
L is —O—, —S—, —SO—, —SO2—, —N(R6)SO2—, —SO2N(R6)—, —N(R6)—, —CO—, —CO2—, —N(R6)CO—, —N(R6)C(O)O—, —N(R6)CON(R6)—, —N(R6)SO2N(R6)—, —N(R6)N(R6)—, —C(O)N(R6)—, —OC(O)N(R6)—, —C(R6)2O—, —C(R6)2S—, —C(R6)2SO—, —C(R6)2SO2—, —C(R6)2SO2N(R6)—, —C(R6)2N(R6)—, —C(R6)2N(R6)C(O)—, —C(R6)2N(R6)C(O)O—, —C(R6)═NN(R6)—, —C(R6)═N—O—, —C(R6)2N(R6)N(R6)—, —C(R6)2N(R6)SO2N(R6)—, or —C(R6)2N(R6)CON(R6)—;
R2 and R2′ are independently selected from —R, -T-W-R6, or R2 and R2′ are taken together with their intervening atoms to form a fused, 5-8 membered, unsaturated or partially unsaturated, ring having 0-3 ring heteroatoms selected from nitrogen, oxygen, or sulfur, wherein each substitutable ring carbon of said fused ring formed by R2 and R2′ is independently substituted by halo, oxo, —CN, —NO2, —R7, or —V-R6, and each substitutable ring nitrogen of said ring formed by R2 and R2′ is independently substituted by R4;
R3 selected from —R, -halo, —OR, —C(═O)R, —CO2R, —COCOR, —COCH2COR, —NO2, —CN, —S(O)R, —S(O)2R, —SR, —N(R4)2, —CON(R7)2, —SO2N(R7)2, —OC(═O)R, —N(R7)COR, —N(R7)CO2(C1-6aliphatic), —N(R4)N(R4)2, —C═NN(R4)2, —C═N—OR, —N(R7)CON(R7)2, —N(R7)SO2N(R7)2, —N(R4)SO2R, or —OC(═O)N(R7)2;
each R is independently selected from hydrogen or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 5-10 ring atoms;
each R4 is independently selected from —R7, —COR7, —CO2(optionally substituted C1-6 aliphatic), —CON(R7)2, or —SO2R7;
each R5 is independently selected from —R, halo, —OR, —C(═O)R, —CO2R, —COCOR, —NO2, —CN, —S(O)R, —SO2R, —SR, —N(R4)2, —CON(R4)2, —SO2N(R4)2, —OC(═O)R, —N(R4)COR, —N(R4)CO2(optionally substituted C1-6 aliphatic), —N(R4)N(R4)2, —C═NN(R4)2, —C═N—OR, —N(R4)CON(R4)2, —N(R4)SO2N(R4)2, —N(R4)SO2R, or —OC(═O)N(R4)2;
V is —O—, —S—, —SO—, —SO2—, —N(R6)SO2—, —SO2N(R6)—, —N(R6)—, —CO—, —CO2—, —N(R6)CO—, —N(R6)C(O)O—, —N(R6)CON(R6)—, —N(R6)SO2N(R6)—, —N(R6)N(R6)N(R6)—, —OC(O)N(R6)—, —OC(O)N(R6)—, —C(R6)2O—, —C(R6)2S—, —C(R6)2SO2—, —C(R6)2SO2—, —C(R6)2SO2N(R6)—, —C(R6)2N(R6)—C(R6)2N(R6)C(O)—, —C(R6)2N(R6)C(O)O—, —C(R6)═NN(R6)—, —C(R6)═N—O—, —C(R6)2N(R6)N(R6)—, —C(R6)2N(R6)SO2N(R6)—, or —C(R6)2N(R6)CON(R6)—;
W is —C(R6)2O—, —C(R6)2S—, —C(R6)2SO—, —C(R6)2SO2, —C(R6)2SO2N(R6)—, —C(R6)2N(R6——CO—, —CO2—, —C(R6)OC(O)—, —C(R6)OC(O)N(R6)—, —C(R6)2N(R6)CO—, —C(R6)2N(R6)C(O)O—, —C(R6)═NN(R6)—, —C(R6)═N—O—, —C(R6)2N(R6)N(R6)—, —C(R6)2N(R6)SO2N(R6)—, —C(R6)2N(R6)CON(R6)—, or —CON(R6)—;
each R6 is independently selected from hydrogen or an optionally substituted C1-4 aliphatic group, or two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to form a 5-6 membered heterocyclyl or heteroaryl ring; and
each R7 is independently selected from hydrogen or an optionally substituted C1-6 aliphatic group, or two R7 on the same nitrogen are taken together with the nitrogen to form a 5-8 membered heterocyclyl or heteroaryl ring,
wherein optional substituents of C6-10 aryl and optional substituents of a heteroaryl ring having 5-10 ring atoms are selected from: a halogen, —R°, —OR°, —SR°, 1,2-methylene-dioxy, 1,2-ethylenedioxy, protected OH, phenyl (Ph), substituted Ph, —O(Ph), substituted —O(Ph), —CH2(Ph), substituted —CH2(Ph), —CH2CH2(Ph), substituted —CH2CH2(Ph), —NO2, —CN, —N(R°)2, —NR°C(O)R°, —NR°C(O)N(R°)2, —NR°CO2R°, —NR°NR°C(O)R°, —NR°NR°C(O)N(R°)2, —NR°NR°CO2R°, —C(O)C(O)R°, —C(O)CH2C(O)R°, —CO2R°, —C(O)R°, —C(O)N(R°)2, —OC(O)N(R°)2, —S(O)2R°, —SO2N(R°)2, —S(O)R°, —NR°SO2N(R°)2, —NR°SO2R°, —C(═S)N(R°)2, —C(═NH)—N(R°)2, —(CH2)y′NHC(O)R°, or —(CH2)y′NHC(O)CH(V′—R°)(R°), wherein each R° is independently selected from hydrogen, a substituted or unsubstituted aliphatic group, an unsubstituted heteroaryl or heterocyclic ring, phenyl (Ph), substituted Ph, —O(Ph), substituted —O(Ph), —CH2(Ph), and substituted —CH2(Ph), wherein y′ is 0-6, wherein V′ is a linker group, and wherein substituents on the aliphatic group or the phenyl ring of R° are selected from amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, and haloalkyl;
wherein optional substituents of C1-6 aliphatic are selected from: the optional substituents of the C6-10 aryl, the optional substituents of the heteroaryl ring, ═O, ═S, ═NNHR*, ═NN(R*)2, ═N—, ═NNHC(O)R*, ═NNHCO2(alkyl), ═NNHSO2(alkyl), and ═NR*, wherein each R* is independently selected from hydrogen, an unsubstituted aliphatic group, and a substituted aliphatic group, and wherein substituents on the aliphatic group are selected from amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, and haloalkyl; and
wherein optional substituents of a heterocyclyl ring having 5-10 ring atoms are selected from: —R+, —N(R+)2, —C(O)R+, —CO2R+, —C(O)C(O)R+, —(O)CH2C(O)R+, —SO2R+, —SO2N(R+)2, —C(═S)N(R+)2, —C(═NH)—N(R+)2, and —NR+SO2R+, wherein each R+ is independently selected from hydrogen, an aliphatic group, a substituted aliphatic group, phenyl (Ph), substituted Ph, —O(Ph), substituted —O(Ph), CH2(Ph), substituted CH2(Ph), and an unsubstituted heteroaryl or heterocyclic ring, wherein substituents on the aliphatic group or the phenyl ring are selected from amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, and haloalkyl.