| US 7,531,507 B2 | ||
| Acylated nonadepsipeptides containing pyridyl alanine residues | ||
| Franz Von Nussbaum, Duesseldorf (Germany); Nina Brunner, Essen (Germany); Rainer Endermann, Wuppertal (Germany); Chantal Fuerstner, Muelheim/Ruhr (Germany); Elke Hartmann, Wuppertal (Germany); Holger Paulsen, Hilden (Germany); Jacques Ragot, Duesseldorf (Germany); Guido Schiffer, Wuppertal (Germany); Joachim Schuhmacher, Wuppertal (Germany); Niels Svenstrup, Velbert (Germany); Joachim Telser, Wuppertal (Germany); Sonja Anlauf, Wuppertal (Germany); and Michael-Alexander Bruening, Berlin (Germany) | ||
| Assigned to AiCuris GmbH & Co. KG, Wuppertal (Germany) | ||
| Filed on Nov. 04, 2005, as Appl. No. 11/267,063. | ||
| Claims priority of application No. 10 2004 053 407 (DE), filed on Nov. 05, 2004. | ||
| Prior Publication US 2006/0264358 A1, Nov. 23, 2006 | ||
| Int. Cl. A61K 38/00 (2006.01); A61K 38/12 (2006.01); A61K 39/00 (2006.01); C07K 7/00 (2006.01); C07K 7/54 (2006.01); C07K 9/00 (2006.01) | ||
| U.S. Cl. 514—9 [514/2; 514/11; 514/15; 530/300; 530/317; 530/328] | 9 Claims |
1. A compound of the formula
 in which
R1 is hydrogen, and
R2 is 2-ethyl-2-methylbut-1-yl, 2,2-diethylbut-1-yl, 2,2-dimethylpent- l-yl or trimethylsilylmethyl,
or
R1 is trifluoromethyl, and
R2 is 2,2-dimethyiprop- l-yl, 2,2-dimethylbut- l-yl, 2-ethyl-2-methylbut- l-yl, 2,2-diethylbut- l-yl, 2,2-dimethylpent- l-yl
or trimethylsilylmethyl,
or one of its salts.
|