US 7,531,503 B2
	Cell scaffold matrices with incorporated therapeutic agents
Anthony Atala, Winston Salem, N.C. (US); James Yoo, Winston Salem, N.C. (US); Grace Lim, Winston-Salem, N.C. (US); Richard Czerw, Clemmons, N.C. (US); Shay Soker, Greensboro, N.C. (US); and Joel Stitzel, Winston-Salem, N.C. (US)
Assigned to Wake Forest University Health Sciences, Winston-Salem, N.C. (US)
Filed on Mar. 18, 2005, as Appl. No. 11/84,350.
Claims priority of provisional application 60/660832, filed on Mar. 11, 2005.
Prior Publication US 2006/0204441 A1, Sep. 14, 2006
Int. Cl. A61K 38/00 (2006.01); A61K 31/70 (2006.01); A61K 33/00 (2006.01); A61K 33/36 (2006.01); A61K 33/32 (2006.01); A61K 33/04 (2006.01)

U.S. Cl. 514—2  [514/23; 424/600; 424/620; 424/641; 977/70]

16 Claims

1. An electrospun matrix having a three-dimensional ultrastructure of interconnected fibers and pores to permit cell attachment and further comprising at least one nanoparticle incorporated within the matrix, wherein the nanoparticle is coupled to a therapeutic agent and the therapeutic agent is releasable from the nanoparticle by application of radiation.