US 7,531,342 B2
	Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences
Ronaldus Adrianus Maria Fouchier, Rotterdam (Netherlands); Bernadetta Gerarda Van Den Hoogen, Rotterdam (Netherlands); Albertus Dominicus Marcellinus Erasmus Osterhaus, Bunnik (Netherlands); Aurelia Haller, Redwood City, Calif. (US); and Roderick Tang, San Carlos, Calif. (US)
Assigned to MedImmune, LLC, Gaithersburg, Md. (US); and ViroNovative BV, Rotterdam (Netherlands)
Filed on Feb. 21, 2003, as Appl. No. 10/371,122.
Application 10/371122 is a continuation in part of application No. PCT/NL02/00040, filed on Jan. 18, 2002.
Claims priority of provisional application 60/358934, filed on Feb. 21, 2002.
Claims priority of application No. 01200213 (EP), filed on Jan. 19, 2001; and application No. 01203985 (EP), filed on Oct. 18, 2001.
Prior Publication US 2004/0005544 A1, Jan. 08, 2004
Int. Cl. C12N 7/01 (2006.01); C12N 7/04 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); C12N 15/00 (2006.01); A61K 39/155 (2006.01)

U.S. Cl. 435—235.1  [435/5; 435/6; 435/320.1; 424/211.1]

15 Claims

1. An isolated negative-sense single stranded RNA virus MPV belonging to the sub-family Pneumovirinae of the family Paramyxoviridae and identifiable as phylogenetically corresponding to the genus Metapneumovirus, wherein the virus is a human virus wherein the amino acid sequence of the N protein of the virus is at least 90% identical to SEQ ID NO:366.