US 7,531,338 B2
Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
Jian Liu, Chapel Hill, N.C. (US); Guoqing Xia, Hamburg (Germany); Jinghua Chen, Chapel Hill, N.C. (US); Michael B. Duncan, Chapel Hill, N.C. (US); Deepak Shukla, Skokie, Ill. (US); Vaibhav Tiwari, Chicago, Ill. (US); and Anders Malmstrom, Lund (Sweden)
Assigned to The University of North Carolina at Chapel Hill, Chapel Hill, N.C. (US); and The Board of Trustees of the University of Illinois, Urbana, Ill. (US)
Appl. No. 10/520,341
PCT Filed Jul. 07, 2003, PCT No. PCT/US03/21094
§ 371(c)(1), (2), (4) Date Oct. 20, 2005,
PCT Pub. No. WO2004/005475, PCT Pub. Date Jan. 15, 2004.
Claims priority of provisional application 60/394199, filed on Jul. 05, 2002.
Prior Publication US 2006/0165673 A1, Jul. 27, 2006
Int. Cl. C12N 9/10 (2006.01); C12N 9/00 (2006.01); C07H 21/04 (2006.01)
U.S. Cl. 435—193  [435/183; 536/23.2] 4 Claims
 
1. An isolated and purified biologically active heparan sulfate 3-O-sulfotransferase 5 polypeptide having the amino acid sequence set forth in SEQ ID NO 2.