| 1. A method for increasing the expression of a target gene induced by β-catenin, comprising contacting a stem cell with an
agent having the structure of formula (I),
wherein A is —(CHR3)— or —(C═O)—, B is —(CHR4)— or —(C═O)—, D is —(CHR5)— or —(C═O)—, E is -(ZR6)— or —(C═O)—, G is —(XR7)n—, —(CHR7)—(NR8)—, —(C═O)—(XR9)—, or —(C═O)—, W is —Y(C═O)—, —(C═O)NH—, —(SO2)— or nothing, Y is oxygen or sulfur, X and Z is independently nitrogen or CH, n=0 or 1; and R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from an amino acid side chain moiety, a derivative of an amino acid side chain moiety, and
stereoisomers thereof, and
wherein the agent is contacted with the stem cell in an amount effective to increase the expression of a target gene induced
by β-catenin.
|
