| US 7,531,310 B2 | ||
| Methods of diagnosing Crohn's disease by measuring expression level of RNA encoding human G-protein coupled receptor, HGPRBMY11 | ||
| John N. Feder, Belle Mead, N.J. (US); and Chandra S. Ramanathan, Ringoes, N.J. (US) | ||
| Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US) | ||
| Filed on Apr. 12, 2006, as Appl. No. 11/403,051. | ||
| Application 11/403051 is a continuation in part of application No. 10/369405, filed on Feb. 14, 2003, abandoned. | ||
| Application 10/369405 is a continuation in part of application No. 09/991225, filed on Nov. 16, 2001, abandoned. | ||
| Claims priority of provisional application 60/305818, filed on Jul. 16, 2001. | ||
| Claims priority of provisional application 60/257611, filed on Dec. 21, 2000. | ||
| Claims priority of provisional application 60/249613, filed on Nov. 17, 2000. | ||
| Prior Publication US 2006/0229272 A1, Oct. 12, 2006 | ||
| Int. Cl. C12Q 1/68 (2006.01); C07K 14/705 (2006.01) | ||
| U.S. Cl. 435—6 [536/24.31] | 4 Claims |
| 1. A method of diagnosing Crohn's disease comprising:
a) measuring the expression level of naturally occurring RNA encoding a polypeptide comprising the sequence of SEQ ID NO:2
or a fragment thereof in a Crohn's colon test sample; and
b) comparing said expression level of said RNA from a normal Crohn's colon sample; wherein an increased expression level of
said RNA in said test sample relative to the expression level of said RNA in said normal sample is indicative of Crohn's disease
or a predisposition to Crohn's disease.
|