| US 7,530,968 B2 | ||
| Hydraulically actuated pump for long duration medicament administration | ||
| Robert R. Gonnelli, Mahwah, N.J. (US) | ||
| Assigned to Valeritas, Inc., Parsippany, N.J. (US) | ||
| Filed on Apr. 23, 2004, as Appl. No. 10/831,354. | ||
| Claims priority of provisional application 60/465070, filed on Apr. 23, 2003. | ||
| Prior Publication US 2005/0119618 A1, Jun. 02, 2005 | ||
| Int. Cl. A61M 37/00 (2006.01) | ||
| U.S. Cl. 604—132 | 36 Claims |

| 1. A hydraulically actuated fluid delivery system for delivery of a liquid medicament, comprising:
(a) a fluid storage chamber for storing said liquid medicament, said fluid storage chamber having an output orifice through
which said liquid medicament can be expelled;
(b) a single expandable pump chamber functionally connected to said fluid storage chamber by a moveable barrier, wherein the
rate of movement of said moveable barrier caused by expansion of said pump chamber is adjustable to produce variable dosing
under patient control;
(c) a hydraulic fluid reservoir functionally connected to a first actuator and having a high viscosity fluid stored therein,
said hydraulic fluid reservoir fluidly connected to said pump chamber by a fixed aperture;
(d) a second actuator which physically acts on said pump chamber, wherein said second actuator is controlled independently
of said first actuator; and
(e) a needle functionally connected to the output orifice for delivery of liquid medicament expelled from said fluid storage
chamber to an individual,
wherein said pump chamber continuously expands upon actuation of said system with said first actuator;
wherein operating said first actuator causes said high viscosity fluid to flow into said pump chamber through said fixed aperture
at a constant rate, thereby displacing said moveable barrier to compress said fluid storage chamber and causing a quantity
of said liquid medicament to be expelled through said orifice;
wherein operating said second actuator independently causes displacement of said moveable barrier to compress said fluid storage
chamber, thereby causing a quantity of said liquid medicament to be expelled; and
wherein concurrently operating both of said first and second actuators causes displacement of the moveable barrier to compress
said fluid storage chamber at an increased rate relative to operating either actuator alone.
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