| US 7,524,985 B2 | ||
| Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor | ||
| Shouji Ochiai, Nakai-machi (Japan); Tetsuro Kawanishi, Nakai-machi (Japan); and Atsushi Matsumoto, Nakai-machi (Japan) | ||
| Assigned to Terumo Kabushiki Kaisha, Tokyo (Japan) | ||
| Filed on Aug. 07, 2007, as Appl. No. 11/890,518. | ||
| Application 11/890518 is a division of application No. 11/187821, filed on Jul. 25, 2005. | ||
| Claims priority of application No. 2004-216535 (JP), filed on Jul. 23, 2004; and application No. 2004-299991 (JP), filed on Oct. 14, 2004. | ||
| Prior Publication US 2008/0021236 A1, Jan. 24, 2008 | ||
| Int. Cl. C07F 5/02 (2006.01) | ||
| U.S. Cl. 562—7 [600/317] | 5 Claims |
1. A fluorescence sensor substance comprising a compound represented by the following formula (7):
 Q and Q′ may be the same or different, may be combined together into a fused ring, and are each a substituent selected from
the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl,
carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups;
and in D10, D20, D30 and D40,
(x) D10 and D20 may be the same or different and are each a substituted or unsubstituted alkyl group, D30 is a hydrogen atom, and D40 is a substituent group represented by the following formula (8), or
(xx) D10 and D20 may be the same or different and are each a substituent group represented by the following formula (9), and D30 and D40 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group
consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl,
carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups:
 X, in a case of said definition (x), is a substituent group selected from the group consisting of —COO—, —OCO—, —CH2NR—, —CH2S—, —CH2O—, —NR—, —NRCO—, —CONR—, —SO2NR—, —NRSO2—, —O—, —S—, —SS—, —NRCOO—, —OCONR— and —CO—, and in a case of said definition (xx), represents a C1 to C30 alkylene group
containing at least one substituent group selected from the group consisting of —COO—, —OCO—, —CH2NR—, —NR—, —NRCO—, —CONR—, —SO2NR—, —NRSO2—, —O—, —S—, —SS—, —NRCOO—, —OCONR— and —CO—, in which R represents a hydrogen atom or a substituted or unsubstituted alkyl
group,
Y comprises one or more of an amino group, carboxy group, sulfo group, nitro group, phosphate group, hydroxyl group, and/or
a group comprising an ether, amide and/or ester linkage,
Z represents —O— or —NR″—,
R″ represents a hydrogen atom or a substituted or unsubstituted alkyl group,
A is a hydrogen atom or a methyl group,
U and U′ may be the same or different and are each a substituted or unsubstituted alkyl group, and
wherein when D10, D20, D30 and D40 have the same meanings as defined under said definition (x), a molar ratio of p to q is from 1:100 to 1:2000, and
wherein when D10, D20, D30 and D40 have the same meanings as defined under said definition (xx), a molar ratio of p to q is from 1:150 to 1:3000.
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