the dashed lines between positions 2-3 and positions 3a-7a in Formula (I) each represent the location for a double bond when X₁R₁ is present;

the dashed lines between positions 3-3a and positions 7a-1 in Formula (I) each represent the location for a double bond when X₂R₂ is present;

the dashed line between position 7 and X₄R₄ in Formula (I) represents the location for a double bond;

X is sulfur, sulfoxo or sulfonyl;

X₁ is absent or is lower alkylene;

X₂ is absent or is lower alkylene;

wherein only one of X₁R₁ and X₂R₂ are present;

X₃ is absent or is lower alkylene or lower alkylidene;

when the dashed line between position 7 and X₄R₄ is absent, then X₄ is absent or is lower alkylene;

when the dashed line between position 7 and X₄R₄ is present, then X₄ is absent;

R₁ is hydrogen, aryl, C₃-C₁₂ cycloalkyl, or heterocyclyl, wherein each of aryl, C₃-C₁₂ cycloalkyl, or heterocyclyl is optionally substituted at one or more positions by halogen, lower alkyl, hydroxy or lower alkoxy;

R₂ is hydrogen, aryl, C₃-C₁₂ cycloalkyl, or heterocyclyl, wherein each of aryl, C₃-C₁₂ cycloalkyl, or heterocyclyl is optionally substituted at one or more positions by halogen, lower alkyl, hydroxy or lower alkoxy;

R₃ is —C(O)-heterocyclyl or -Z-N(R₆)-Z₁R₇ (optionally substituted on heterocyclyl by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, lower alkoxy-lower alkylene-, hydroxy-alkylene-, aryloxy or arylalkoxy);

when the dashed line between position 7 and X₄R₄ is absent, then R₄ is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, aryl (optionally substituted on aryl at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen, heterocyclyl (optionally substituted on heterocyclyl at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen) or C₃-C₁₂ cycloalkyl (optionally substituted on C₃-C₁₂ cycloalkyl at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen);

when the dashed line between position 7 and X₄R₄ is present, then R₄ is CH-aryl (optionally substituted on aryl at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen) or CH-heterocyclyl (optionally substituted on heterocyclyl at one or more positions by hydroxy, lower alkyl, lower alkoxy or halogen);

R₆ and R₇ are each individually hydrogen, lower alkyl, —NR₈R₉, aryl (optionally substituted on aryl by one or more hydroxy, halogen, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy or arylalkoxy), C₃-C₁₂ cycloalkyl (optionally substituted on C₃-C₁₂ cycloalkyl by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, hydroxy-alkylene-, aryloxy, arylalkoxy or lower alkylene) or heterocyclyl (optionally substituted on heterocyclyl by one or more hydroxy, halogen, amino, lower alkyl, carboxy, alkoxycarbonyl, lower alkoxy, lower alkoxy-lower alkylene-, hydroxy-alkylene-, aryloxy or arylalkoxy);

R₈ and R₉ are each individually hydrogen, alkyl, heterocyclyl, C₃-C₁₂ cycloalkyl, or aryl (optionally substituted on aryl by one or more lower alkyl, hydroxy, alkoxy, halogen, heterocyclyl or aryl-lower alkylene-);

Z is carbonyl or sulfonyl;

Z₁ is absent; or is lower alkylene optionally substituted at one or more positions by halogen, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl;

or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof.