| US 7,524,938 B2 | ||
| Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins | ||
| Irit Sagi, Rehovot (Israel); and Tamar Danon, Rehovot (Israel) | ||
| Assigned to Yeda Research And Development Co., Ltd., Rechovot (Israel) | ||
| Appl. No. 10/551,715 PCT Filed Apr. 04, 2004, PCT No. PCT/IL2004/000308 § 371(c)(1), (2), (4) Date Jul. 20, 2006, PCT Pub. No. WO2004/087042, PCT Pub. Date Oct. 14, 2004. |
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| Claims priority of provisional application 60/460005, filed on Apr. 04, 2003. | ||
| Prior Publication US 2007/0172482 A1, Jul. 26, 2007 | ||
| Int. Cl. C12P 21/08 (2006.01); C12N 9/52 (2006.01); C07K 16/00 (2006.01); A61K 31/49 (2006.01) | ||
| U.S. Cl. 530—388.26 [530/391.5; 514/185; 540/145] | 6 Claims |
| 1. A method of producing an antibody which inhibits an activity of gelatinase B, the method comprising:
(a) generating antibodies using a hapten comprising transition metal ion-bound chelator, wherein said chelator comprises substituted
porphyrin; and
(b) testing an inhibitory effect of said antibodies on the gelatinase B, thereby producing the antibody which inhibits an
activity of gelatinase B.
|