US 7,524,875 B2
Modified bio-related substance, process for producing the same, and intermediate
Ken-ichiro Nakamoto, Kanagawa (Japan); Syunsuke Ohashi, Kanagawa (Japan); Yuji Yamamoto, Tokyo (Japan); Kenji Sakanoue, Kanagawa (Japan); Chika Itoh, Kanagawa (Japan); and Tohru Yasukohchi, Kanagawa (Japan)
Assigned to NOF Corporation, Tokyo (Japan)
Filed on Jun. 02, 2005, as Appl. No. 11/142,255.
Application 11/142255 is a continuation in part of application No. 10/716432, filed on Nov. 20, 2003.
Claims priority of application No. P. 2002-337113 (JP), filed on Nov. 20, 2002.
Prior Publication US 2005/0288490 A1, Dec. 29, 2005
Int. Cl. A61K 31/075 (2006.01); A61K 31/4015 (2006.01); A61K 31/4164 (2006.01); A61K 31/4192 (2006.01); C07C 43/11 (2006.01); C07D 207/444 (2006.01); C07D 233/64 (2006.01); C07D 249/04 (2006.01); C07D 487/06 (2006.01)
U.S. Cl. 514—359  [514/385; 514/718; 548/255; 548/334.1; 548/530; 568/625] 29 Claims
 
1. A modified bio-related substance, comprising a bio-related substance and at least one poly(alkylene glycol)oxy group bonded to said bio-related substance, said at least one poly(alkylene glycol)oxy group being represented by the following formula (1):

OG Complex Work Unit Drawing
wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000, wherein said modified bio-related substance is formed by reacting a functional group X of an intermediate represented by formula (2) with a functional group of the bio-related substance:

OG Complex Work Unit Drawing
wherein X is at least one selected from the group consisting of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (xx1), (xx2) and (xx3):

OG Complex Work Unit Drawing
wherein Z represents a linking group containing an alkylene group or an alkylene group containing an ether bond, an ester bond, a urethane bond, an amide bond, a carbonate bond, or a secondary amino group and Y represents a hydrocarbon group having 1 to 10 carbon atoms which may contain fluorine atom(s); and W1 represents a halogen atom selected from Cl, Br and I.