A is selected from the group consisting of (C1-C6) alkyl, (C3-C6) alkenyl and (C3-C6) alkynyl, optionally substituted with one or more substituents selected from the group consisting of (C1-C5) alkyl, (C2-C5) alkenyl, (C2-C5) alkynyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, arylalkyl, heteroarylalkyl, aryl, heteroaryl and halogen,

R1 is —NR6R7, (C4-C7) azacycloalkyl, (C5-C7) azacycloalkenyl, (C5-C9) azabicycloalkyl or (C5-C9) azabicycloalkenyl, optionally all of the aforementioned groups are substituted with one or more substituents selected from the group consisting of (C1-C5) alkyl, (C3-C5) cycloalkyl and halogen,

A-R1 is such that the nitrogen of R1 and the nitrogen in the 1-position of the pyrazole are necessarily separated by at least two carbon atoms,

R3 is H, halogen, OH, SH, NH2, ORc, SRc, SORa, SO2Ra, NHCHO, NRaRb, NHC(O)Ra, NHC(S)Ra or NHSO2Ra;

R4 is aryl or heteroaryl optionally substituted with one or more substituents selected from the group consisting of halogen, CN, NO₂, NH₂, OH, SH, COOH, CHO, C(O)NH₂, C(S)NH₂, SO₂H, SO₂NH₂, NHCHO, C(O)Ra, C(O)ORa, C(O)NRaRb, C(S)NRaRb, S(O)Ra, SO₂Ra, SO₂NRaRb, ORc, SRc, O—C(O)Ra, —O—C(S)Ra, NRaRb, NHC(O)Ra, NHC(S)Ra, NHCONH₂, NHCONRaRb, NHSO₂Ra, aryl, heteroaryl, (C4-C7) heterocycloalkyl, polyfluoroalkyl, trifluoromethylsulfanyl, trifluoromethoxy, linear or branched (C1-C6) alkyl, (C2-C6) alkenyl and (C2-C6) alkynyl, these substituents being optionally substituted with one or more substituents selected from the group consisting of alkyl, halogen, OH, and methoxy;

R5 is H, halogen, CF₃, CHF₂, CH₂F, linear or branched (C1-C6) alkyl or (C3-C7) cycloalkyl,

Ra is linear or branched (C1-C6) alkyl, alkenyl, alkynyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, (C4-C7) heterocycloalkyl, arylalkyl, heteroarylalkyl, aryl, heteroaryl or polyfluoroalkyl,

Rb is, independently of Ra, a hydrogen, linear or branched (C1-C6) alkyl, alkenyl, alkynyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, (C4-C7) hetero cycloalkyl, arylalkyl, heteroarylalkyl, aryl, heteroaryl or polyfluoroalkyl, or

Ra and Rb taken together with the nitrogen atom to which they are attached form a saturated or unsaturated ring containing 5, 6 or 7 ring members, optionally containing one or more additional heteroatoms, wherein said heteroatoms are O, S or N, and wherein said ring is optionally substituted with one or more alkyls and/or halogens,

Rc is linear or branched (C1-C6) alkyl, (C3-C6) alkenyl, (C3-C6) alkynyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, (C4-C7) heterocycloalkyl,

heteroarylalkyl, heteroaryl, polyfluoroalkyl, C(O)R8, C(S)R8 or SO₂R8,

R6 and R7 are, independently of one another, a hydrogen, (C1-C6) alkyl, (C3-C6) alkenyl, (C3-C6) alkynyl, (C3-C7) cycloalkyl, (C5-C7) cycloalkenyl, (C4-C7) heterocycloalkyl, an arylalkyl or heteroarylalkyl, or

R6 and R7 taken together with the nitrogen atom to which they are attached form a saturated or unsaturated ring with 5, 6 or 7 ring members, optionally containing one or more additional heteroatoms, wherein said heteroatoms are O, S or N and and wherein said ring is optionally substituted with one or more alkyls and/or halogens; and

R8 is Ra or NRaRb;

or a racemate, an enantiomer or a diastereoisomer, or a mixture in any combination thereof, a tautomer or a pharmaceutically acceptable salt thereof, with the exception of 3-(3-pyridinyl)-1H-pyrazole-1-butanamine, 4-(3-pyridinyl)-1H-pyrazole-1-butanamine and N-(diethyl)-4-phenyl-1H-pyrazole-1-ethylamine.