US 7,524,821 B2
	Scaffolded maleimide clusters for multivalent peptide assembly
Lai-Xi Wang, Ellicott City, Md. (US); Jiahong Ni, Baltimore, Md. (US); Hengguang Li, Baltimore, Md. (US); and Suddham Singh, Durham (United Kingdom)
Assigned to University of Maryland Biotechnology Institute, Baltimore, Md. (US)
Appl. No. 10/518,108 PCT Filed Jun. 20, 2003, PCT No. PCT/US03/19779 § 371(c)(1), (2), (4) Date Dec. 10, 2004, PCT Pub. No. WO04/000802, PCT Pub. Date Dec. 31, 2003.
Claims priority of provisional application 60/390776, filed on Jun. 20, 2002.
Prior Publication US 2005/0159341 A1, Jul. 21, 2005
Int. Cl. A61K 31/70 (2006.01); A01N 43/04 (2006.01)

U.S. Cl. 514—25  [514/2; 514/23]

10 Claims

1. A maleimide cluster comprising a core carbohydrate molecule wherein the core is selected from the group consisting of monosaccharides, oligosaccharides, and cyclic oligosaccharides and wherein at least two or more maleimide containing groups are attached to the core, wherein the maleimide containing groups are linked to the carbohydrate core by an alkyl cysteamine linker and optionally comprising a protein is covalently attached to the maleimide.