US 7,524,815 B2
	Osteoprotegerin in milk
Karine Vidal, Lausanne (Switzerland); Peter Van Den Broek, WJ Maarn (Netherlands); Elizabeth Offord Cavin, Poliez-Pittet (Switzerland); and Anne Donnet-Hughes, Saint-Legier (Switzerland)
Assigned to Nestec S.A., Vevey (Switzerland)
Filed on Jun. 02, 2005, as Appl. No. 11/144,236.
Application 11/144236 is a division of application No. 10/676358, filed on Oct. 02, 2003.
Application 10/676358 is a continuation of application No. PCT/EP02/02912, filed on Mar. 15, 2002.
Claims priority of application No. 01108414 (EP), filed on Apr. 03, 2001.
Prior Publication US 2005/0288219 A1, Dec. 29, 2005
Int. Cl. A61K 38/17 (2006.01)

U.S. Cl. 514—8  [514/2; 514/12; 530/350; 424/9.1; 435/69.1; 426/656]

4 Claims

1. A method for the treatment of disorders associated with bone remodeling which comprises administering to a person in need of such treatment an effective amount for the treatment or prophylaxis of a disorder associated with bone remodeling, of an ingestible composition of osteoprotegerin obtainable from bovine milk or colostrum, wherein the osteoprotegerin has a glycosylation pattern giving rise to a polypeptide having a molecular weight of approximately 130 kDa, and wherein the ingestible composition includes a food material selected from the group consisting of milk, yogurt, curd, cheese, fermented milks, milk-based fermented products, ice-creams, fermented cereal-based products, milk-based powders, infant formulae, pet food and combinations thereof.