US 7,524,811 B2
	Anti-angiogenic peptides from the N-terminus of endostatin
Judah Folkman, Brookline, Mass. (US); Kashi Javaherian, Lexington, Mass. (US); and Robert Tjin Tham Sjin, Framingham, Mass. (US)
Assigned to Children's Medical Center Corporation, Boston, Mass. (US)
Filed on Feb. 28, 2006, as Appl. No. 11/364,855.
Application 11/364855 is a continuation in part of application No. PCT/US2004/028143, filed on Aug. 30, 2004.
Claims priority of provisional application 60/499264, filed on Aug. 29, 2003.
Claims priority of provisional application 60/539213, filed on Jan. 26, 2004.
Prior Publication US 2006/0251699 A1, Nov. 09, 2006
Int. Cl. A61K 38/04 (2006.01); A61K 38/16 (2006.01)

U.S. Cl. 514—2

22 Claims

1. An isolated peptide consisting of 10 to 35 amino acids of the N-terminal region of a human endostatin protein including the first histidine of the human endostatin protein excluding SEQ ID NOs 48, 58 and 118, wherein the isolated peptide has anti-tumor or anti-angiogenic activity.