US 7,524,517 B2
	Methods and compositions for P2X receptor calcium entry channels and other calcium entry mechanisms
Erik Schwiebert, Birmingham, Ala. (US); and Akos Zsembery, Budapest (Hungary)
Assigned to UAB Research Foundation, Birmingham, Ala. (US)
Appl. No. 10/542,555 PCT Filed Jan. 20, 2004, PCT No. PCT/US2004/001298 § 371(c)(1), (2), (4) Date Aug. 29, 2005, PCT Pub. No. WO2004/064742, PCT Pub. Date Aug. 05, 2004.
Claims priority of provisional application 60/476423, filed on Jun. 06, 2003.
Claims priority of provisional application 60/441045, filed on Jan. 17, 2003.
Prior Publication US 2006/0121128 A1, Jun. 08, 2006
Int. Cl. A61K 33/30 (2006.01); A61K 31/315 (2006.01); A61K 31/7076 (2006.01); A61P 11/00 (2006.01); A61P 11/06 (2006.01)

U.S. Cl. 424—641  [424/643; 424/682; 514/47; 514/255.06; 514/494; 514/669; 514/826; 514/851; 514/924]

13 Claims

1. A method of increasing cytosolic Ca2+ levels in an airway epithelial cell comprising contacting P2X receptors on the cell with an effective amount of Zn2+ and one or more of the following molecules: ATP; α, β-methylene-ATP; benzoyl-benzoyl-ATP; ATPγS; or AMPPNP, wherein there is a sustained elevation in cytosolic Ca2+ levels in the cell.