US 7,361,759 B2
Method for producing L-biopterin
Shinnosuke Tazawa, Chiba (Japan)
Assigned to Shiratori Pharmaceutical Co., Ltd, Narashino-shi (Japan); and Asubio Pharma Co., Ltd., Tokyo (Japan)
Filed on Feb. 28, 2005, as Appl. No. 11/66,255.
Claims priority of application No. 2004-375618 (JP), filed on Dec. 27, 2004.
Prior Publication US 2006/0142573 A1, Jun. 29, 2006
Int. Cl. C07D 475/04 (2006.01); C07H 19/19 (2006.01)
U.S. Cl. 544—259  [536/27.4] 14 Claims
 
1. A method for producing a compound represented by formula (6):

OG Complex Work Unit Drawing
wherein R1 and R2, which are the same or different from each other, each represents a hydrogen atom, an alkyl group, or an aryl group, comprising:
reacting a triacetoxy-5-deoxy-L-arabinose phenylhydrazone of formula (4):

OG Complex Work Unit Drawing
wherein R1 and R2 which are the same or different from each other, each represents a hydrogen atom, an alkyl group, or an aryl group;
with 6-hydroxy-2,4,5-triaminopyrimidine (5) under catalytic influence of a Lewis acid in an aqueous solvent.