US 7,521,696 B2
Method and apparatus for analyzing a dynamic sample
Patrick Courtney, Ealing (United Kingdom); Robert Hoult, Beaconsfield (United Kingdom); Alistair Fitch, Maidenhead (United Kingdom); Steve Bush, Hibil Wycombe (United Kingdom); Shab Ladha, Chalfont St Gales (United Kingdom); and Colin Blackmore, Welwyn Garden City (United Kingdom)
Assigned to PerkinElmer Singapore PTE Ltd., Singapore (Singapore)
Appl. No. 11/718,788
PCT Filed Dec. 21, 2005, PCT No. PCT/GB2005/004954
§ 371(c)(1), (2), (4) Date Nov. 16, 2007,
PCT Pub. No. WO2006/067426, PCT Pub. Date Jun. 29, 2006.
Claims priority of application No. 0428044.2 (GB), filed on Dec. 22, 2004; and application No. 0515845.6 (GB), filed on Aug. 02, 2005.
Prior Publication US 2008/0217557 A1, Sep. 11, 2008
Int. Cl. G01N 21/64 (2006.01)
U.S. Cl. 250—459.1 10 Claims
OG exemplary drawing
 
1. A method of analyzing a sample of biological material including components tagged with respective fluorescent labels, the method comprising the steps of: identifying a specific labeled component to be monitored; and irradiating with an energy beam at least one region of the sample which substantially surrounds said specific component so as to modify the optical properties of labels in the region, such that the label associated with said specific component is distinguishable from those in the region associated with components moving relative to said specific component.