represents one or two double bonds in the 5-membered ring of I, and the six-membered ring of I is an aromatic ring;

n is 1 or 2;

R is;

X and Z are the same or different and are independently selected from the group consisting of CH₂, CH, C═O, C═CR₃R₄, C═S, C═NR₃, and CR₃R₄, wherein R₃ and R₄ are alkyl or aryl;

A is selected from the group consisting of hydrogen (H), alkyl, cycloalkyl which is cyclopentyl phenyl, phenylalkyl, heteroarylalkyl, where heteroaryl is pyrazolyl, oxazolyl or isooxazolyl, cycloheteroalkyl which is pyrrolidinyl, piperidinyl, tetrahydropyranyl or tetrahydrothiopyranyl, cycloheteroalkylalkyl where the cycloheteroalkyl group is tetrahydrofuranyl, pyrrolidinyl, oxazolidinyl, or thiazolidinyl, —C(O)—NR₁R₂, or —C(O)—OR₁, wherein any such group may optionally be substituted with 1 to 3 substituents (where possible) independently selected from the group consisting of hydrogen, halo, alkyl, polyhaloalkyl, alkoxy, haloalkoxy, polyhaloalkoxy, carboxy, alkoxycarbonyl, cycloalkyl, heteroarylamino, cycloheteroalkyl, cycloheteroalkylalkyl, cyclopropylsulfonyl, cycloheteroalkylaminocarbonyl, cycloheteroalkylcarbonyl, heteroarylaminocarbonyl, cycloheteroalkyl(alkyl)aminocarbonyl, cycloalkylsulfonyl(alkyl)amino, hydroxy, hydroxyalkyl, cyano, amino, substituted amino, alkylamino, dialkylamino, alkylthio, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, (where the alkyls are the same or different), alkylcarbonylamino, alkylsulfonylamino, alkylaminocarbonylamino, alkoxycarbonylamino, alkylsulfonyl, phenylsulfonyl, alkylsulfinyl, and sulfonyl;

wherein heteroaryl in the above substituents is pyrazolyl, isooxazolyl, pyridinyl, or pyrimidinyl; and

wherein cycloheteroalkyl in the above substituents is tetrahydrofuranyl, pyrrolidinyl, oxazolidinyl, thiazolidinyl, tetrahydropyranyl, piperidinyl, morpholinyl, piperazinyl, or indolinyl;

R₁ and R₂ are the same or different and are each indepedently selected from the group consisting of hydrogen (H), alkyl, phenyl, phenylalkyl, heteroaryl which is pyrazolyl, heteroarylalkyl which is pyrazolylalkyl or pyridinylalkyl, cycloheteroalkyl which is tetrahydropyranyl or piperidinyl, wherein such group may optionally be substituted with 1 to 3 substitutents (where possible) independently selected from the group consisting of hydrogen, and alkyl; and

Y is phenyl, wherein said phenyl group may optionally be substituted with 1-5 substituents independently selected from the group consisting of hydrogen, and halo; or a pharmaceutically acceptable salt thereof, all stereoisomers thereof.