| US 7,521,544 B2 | ||
| Method and apparatus for the use of [11C] carbon monoxide in labeling synthesis by photo-initiated carbonylation | ||
| Tor Kihlberg, Uppsala (Sweden); Oleksiy Itsenko, Uppsala (Sweden); Tommy Ferm, Uppsala (Sweden); and Bengt Langstrom, Uppsala (Sweden) | ||
| Assigned to GE Healthcare Limited, Buckinghamshire (United Kingdom) | ||
| Appl. No. 10/576,918 PCT Filed Oct. 25, 2004, PCT No. PCT/IB2004/003488 § 371(c)(1), (2), (4) Date Apr. 24, 2006, PCT Pub. No. WO2005/042441, PCT Pub. Date May 12, 2005. |
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| Claims priority of provisional application 60/516525, filed on Oct. 31, 2003. | ||
| Prior Publication US 2007/0043213 A1, Feb. 22, 2007 | ||
| Int. Cl. C07F 5/00 (2006.01); C07C 233/02 (2006.01); B01J 19/08 (2006.01) | ||
| U.S. Cl. 534—11 [204/157.89; 422/159; 422/186; 564/123] | 7 Claims |
| 1. A method for labeling synthesis, comprising:
(a) providing a UV reactor assembly comprising a high pressure reaction chamber, a UV lamp and a concave mirror, wherein the
high pressure reaction chamber comprises a window facing the concave mirror, a liquid inlet and a gas inlet in a bottom surface
thereof,
(b) providing a reagent volume to be labeled,
(c) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber of the UV reactor assembly via the
gas inlet,
(d) introducing at high pressure said reagent into the reaction chamber via the liquid inlet,
(e) turning on the UV lamp and waiting for a predetermined time while the labeling synthesis occur, and
(f) removing the labeled product from the reaction chamber.
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