US 7,521,434 B2
	Cross-linked gels of hyaluronic acid with hydrophobic polymers and processes for making them
Adelya K. Leshchiner, Cresskill, N.J. (US); Nancy E. Larsen, Highland Mills, N.Y. (US); and Edward G. Parent, North Bergen, N.J. (US)
Assigned to Luromed LLC, Tarrytown, N.Y. (US)
Filed on Jun. 27, 2006, as Appl. No. 11/475,200.
Claims priority of provisional application 60/694088, filed on Jun. 27, 2005.
Prior Publication US 2006/0293277 A1, Dec. 28, 2006
Int. Cl. A61K 31/728 (2006.01); A61K 31/715 (2006.01)

U.S. Cl. 514—54  [514/23; 536/123.1; 536/124]

35 Claims

1. A method of preparing a cross-linked gel of hyaluronic acid, said method comprising subjecting sodium hyaluronate in a dilute aqueous alkaline solution at a pH of not less than about 9 to a cross-linking reaction with at least one vinyl functionalized silicone compound as the cross-linking agent at about 20° C.