	US 7,521,181 B2
	Methods of diagnosing risk of myocardial infarction by detection of polymorphisms in connexin and NADH/NADPH oxidase genes
Yoshiji Yamada, Nagoya (Japan); and Mitsuhiro Yokota, Nagoya (Japan)
Assigned to Nagoya Industrial Science Research Institute, Nagoya-shi (Japan)
Appl. No. 10/517,605 PCT Filed Mar. 20, 2003, PCT No. PCT/JP03/03477 § 371(c)(1), (2), (4) Date Dec. 21, 2004, PCT Pub. No. WO04/001037, PCT Pub. Date Dec. 31, 2003.
Claims priority of application No. 2002-181580 (JP), filed on Jun. 21, 2002.
Prior Publication US 2005/0260124 A1, Nov. 24, 2005
Int. Cl. C12Q 1/68 (2006.01)

U.S. Cl. 435—6

1 Claim

1. A method for diagnosing the risk of myocardial infarction, comprising the following steps (i) to (iii):

(i) analyzing two polymorphisms (1) and (2) in a nucleic acid sample:

(1) polymorphism at the base number position 1019 of the connexin 37 gene; and

(2) polymorphism at the base number position 242 of the NADH/NADPH oxidase p22 phox gene;

(ii) determining, based on the information about said polymorphism which was obtained in the step (i), the genotype of the nucleic acid sample; and

(iii) assessing, based on the genotype determined, a genetic risk of myocardial infarction.