| US 7,519,145 B2 | ||
| Flow method and apparatus for screening chemicals using micro x-ray fluorescence | ||
| Benjamin P. Warner, Los Alamos, N. Mex. (US); George J. Havrilla, Los Alamos, N. Mex. (US); Thomasin C. Miller, Bartlesville, Okla. (US); Cris Lewis, Los Alamos, N. Mex. (US); Cynthia A. Mahan, Los Alamos, N. Mex. (US); and Cyndi A. Wells, Los Alamos, N. Mex. (US) | ||
| Assigned to Los Alamos National Security, LLC, Los Alamos, N. Mex. (US) | ||
| Filed on May 31, 2006, as Appl. No. 11/444,660. | ||
| Application 11/444660 is a continuation in part of application No. 11/125036, filed on May 09, 2005, abandoned. | ||
| Application 11/125036 is a continuation of application No. 10/206524, filed on Jul. 25, 2002, abandoned. | ||
| Prior Publication US 2007/0003008 A1, Jan. 04, 2007 | ||
| Int. Cl. G01N 23/223 (2006.01) | ||
| U.S. Cl. 378—47 | 12 Claims |
| 1. A method for determining whether or not chemical binding occurs between at least one target binder and at least one chemical
to form a bound complex, comprising:
preparing a solution comprising at least one chemical and at least one target binder;
flow-separating the solution into at least two separated components;
exciting atoms of the chemical and of a chemical portion of any bound complex present in any flow separated component with
a polychromatic x-ray excitation beam in order to produce an x-ray fluorescence signal therefrom;
detecting the x-ray fluorescence signal produced from the excited atoms present in the chemical and the chemical portion of
any bound complex present in a separated component; and
determining from the x-ray fluorescence signal produced from the excited atoms present in the chemical and the chemical portion
of any bound complex present in a separated component whether or not any separated component comprises a bound complex.
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