US 7,517,990 B2
	Method for deuteration of a heterocyclic ring
Nobuhiro Ito, Kawagoe (Japan); Tsuneaki Maesawa, Kawagoe (Japan); Kazushige Muto, Kawagoe (Japan); Kosaku Hirota, Gifu (Japan); and Hironao Sajiki, Gifu (Japan)
Assigned to Wako Pure Chemical Industries, Ltd., Osaka-shi, Osaka (Japan)
Appl. No. 10/534,344 PCT Filed Nov. 07, 2003, PCT No. PCT/JP03/14181 § 371(c)(1), (2), (4) Date May 09, 2005, PCT Pub. No. WO2004/046066, PCT Pub. Date Jun. 03, 2004.
Claims priority of application No. 2002-331594 (JP), filed on Nov. 15, 2002.
Prior Publication US 2006/0025596 A1, Feb. 02, 2006
Int. Cl. C07D 295/03 (2006.01); C07D 207/06 (2006.01)

U.S. Cl. 546—184  [548/400]

5 Claims

1. A method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to a sealed refluxing state in a deuterated solvent in the presence of an activated palladium catalyst.