a. an applicator configured to apply a pathology differentiating agent on a living tissue sample under analysis, wherein said pathology differentiating agent provokes a transient alteration in an optical property of said living tissue sample;

b. a light source configured to illuminate the living tissue sample with broad band, continuous wave optical radiation;

c. one or more optical filters configured to select a spectral band of light for imaging and/or illumination;

d. an optical imaging head comprising:

i. optics for collecting and focusing light remitted by the living tissue sample under analysis; and

ii. one or more optical imaging detectors connected with a data digitizing board and a computer for capturing a plurality of images of the living tissue sample at various time instances, before and after the application of said pathology differentiating agent;

e. a probing device, wherein said device facilitates the visualization and imaging of the living tissue sample;

f. a mechanical shaft connecting said optical imaging head with said probing device, whereby a relative motion between said living tissue sample and the optical imaging head is substantially eliminated and captured images in time succession are substantially registered or aligned; and

wherein said computer comprises data storage, processing and analysis software, and hardware,

said computer programmed to perform modeling and parametric analysis of a pixel value (PV_XY) vs. time curve obtained from a pixel value (PV_XY) for a given XY spatial location in the plurality of images of said living tissue sample at various time instances, and programmed to calculate a dynamic optical property based on the curve of (PV_XY) vs. time over a time-course that encompasses both (i) a rising interval in a pixel value (PV_XY) vs. time curve obtained from a pixel value PV_XY for a given XY spatial location in the plurality of images of said living tissue sample captured at the various time instances, said rising interval occurring between said application of said pathology differentiating agent and a maximum value of said pixel value (PV_XY) in said pixel value vs. time curve, and (ii) a relaxation time interval in said pixel value (PV_XY) vs. time curve, said relaxation time interval occurring after said maximum value of (PV_XY) until a substantial ending time of said transient alteration, wherein said dynamic optical property is an area under the pixel value (PV_XY) vs. time curve; and

wherein said computer is programmed to convert said dynamic optical property to a pathology index by correlating and calibrating said dynamic optical property with a diagnosis to detect a tissue abnormality in said living tissue sample;

wherein said computer is programmed to calculate said dynamic optical property at each of a plurality of spatial pixel locations and to create and display a first image, wherein said first image expresses the spatial distribution of said dynamic optical property or said image expresses a spatial distribution of said pathology index;

wherein said dynamic optical property calculated at a plurality of spatial pixel locations or a plurality of said pathology indices calculated at a plurality of spatial locations are represented using a scale of pseudocolors, thereby generating a dynamic optical property pseudocolor image or a pathology pseudocolor image.