| US 7,514,534 B2 | ||
| Metalloproteinase-binding proteins | ||
| Daniel T. Dransfield, Hanson, Mass. (US); Kristin Rookey, Revere, Mass. (US); and Robert C. Ladner, Ijamsville, Md. (US) | ||
| Assigned to DYAX Corp., Cambridge, Mass. (US) | ||
| Filed on Nov. 19, 2004, as Appl. No. 10/993,543. | ||
| Claims priority of provisional application 60/523745, filed on Nov. 19, 2003. | ||
| Prior Publication US 2006/0036076 A1, Feb. 16, 2006 | ||
| Int. Cl. C07K 14/725 (2006.01); C07K 16/46 (2006.01); A61K 39/00 (2006.01) | ||
| U.S. Cl. 530—350 [530/387.3; 424/133.1] | 13 Claims |
| 1. An isolated protein which binds to matrix metalloproteinase 26 (MMP-26), said protein comprising a heavy chain immunoglobulin
variable domain (HC) sequence and a light chain immunoglobulin variable domain (LC) sequence, wherein
(a) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:4 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:2;
(b) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:8 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:6;
(c) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:12 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:10;
(d) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:16 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:14;
(e) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:52 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:50;
(f) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:104 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:102;
(g) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:132 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:130;
(h) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:148 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:146;
(i) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:164 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:162; or
(j) the HC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:180 and the LC comprises CDR1, CDR2, and CDR3 of SEQ ID NO:178.
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