| US 7,514,464 B2 | ||
| Substituted arylpyrazoles | ||
| Denis Billen, Sandwich (United Kingdom); Nathan Anthony Logan Chubb, Sandwich (United Kingdom); David Morris Gethin, Sandwich (United Kingdom); Kim Thomas Hall, Sandwich (United Kingdom); Lee Richard Roberts, Sandwich (United Kingdom); and Nigel Derek Arthur Walshe, Sandwich (United Kingdom) | ||
| Assigned to Pfizer Limited, Sandwich, Kent (United Kingdom) | ||
| Filed on Jun. 15, 2005, as Appl. No. 11/153,103. | ||
| Application 11/153103 is a continuation in part of application No. 11/013176, filed on Dec. 15, 2004. | ||
| Claims priority of provisional application 60/571337, filed on May 13, 2004. | ||
| Claims priority of application No. 0329314.9 (GB), filed on Dec. 08, 2003. | ||
| Prior Publication US 2006/0014802 A1, Jan. 19, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 31/4439 (2006.01); C07D 231/10 (2006.01) | ||
| U.S. Cl. 514—406 [548/377.1] | 16 Claims |
1. A combination product comprising a compound of formula (I):
 R1 is CF3, OCF2H, OCF3, —SCF3, —SOCF3, —SO2CF3, or SF5;
R2 is H, fluoro, or C1-4 alkyl optionally substituted by 1 to 5 halogen atoms independently selected from chloro and fluoro;
R3, R4, R5, and R6 are independently selected from H, Cl, F, or C1-4 alkyl optionally substituted by 1 to 5 halogen groups independently selected from chloro and fluoro;
R7 is Cl or fluoro;
X is CR8 where R8 is Cl or fluoro; and
R9 is NRaRb;
Ra is selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-8 cycloalkyl, C(O)OC1-6 alkyl and C1-6 alkanoyl, wherein each of the above groups may include one or more optional substituents where chemically possible independently
selected from halo, phenyl, hydroxy, —C(O)OH, —C(O)O C1-6 alkyl, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkyl amino and di C1-6 alkyl amino;
Rb is selected from hydrogen, C1-6 alkyl, C2-6 alkenyl, C1-6 alkanoyl and C(O)OC1-6 alkyl, wherein each of the above groups may include one or more optional substituents where chemically possible independently
selected from, halo, phenyl, hydroxy, —COOH, —C(O)O C1-6 alkyl, C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, amino, C1-6 alkyl amino and di C1-6 alkyl amino;
or a pharmaceutically acceptable salt or prodrug thereof;
with the proviso that at least one of R2, R3, R4, R5, or R6 is fluoro, with one or more other biologically active compounds.
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