R is an unsubstituted aryl or aryl substituted with one or more moieties which moieties can be the same or different, each moiety being independently selected from the group consisting of halogen, CN, —OR⁵, SR⁵, —CH₂OR⁵, —C(O)R⁵, —SO₃H, —S(O)₂R⁶, —S(O)₂NR⁵R⁶, —NR⁵R⁶, —C(O)NR⁵R⁶, —CF₃, —OCF₃ and heterocyclyl;

R² is selected from the group consisting of R⁹, alkyl(C₂-C₆), alkynyl, alkynylalkyl, cycloalkyl, —CF₃, —C(O)₂R⁶, aryl, arylalkyl, heteroarylalkyl, heterocyclyl, alkyl substituted with 1-6 R⁹ groups which groups can be the same or different with each R⁹ being independently selected, aryl substituted with 1-3 aryl or heteroaryl groups which can be the same or different and are independently selected from phenyl, pyridyl, thiophenyl, furanyl and thiazolo groups,

R³ is selected from the group consisting of H, halogen, —NR⁵R⁶, —C(O)NR⁵R⁶ alkyl, alkynyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl and heteroarylalkyl,

 wherein each of said alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl and heteroarylalkyl for R³ and the heterocyclyl moieties whose structures are shown immediately above for R³ can be substituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF₃, CN, —OCF₃, —(CR⁴R⁵)_nOR⁵, —OR⁵, —NR⁵R⁶ , —(CR⁴R⁵)_nNR⁵R⁶, —C(O)₂R⁵, —C(O)R⁵, —C(O)NR⁵R⁶, —SR⁶, —S(O)₂R⁶, —S(O)₂NR⁵R⁶, —N(R⁵)S(O)₂R⁷, —N(R⁵)C(O)⁷ and —N(R⁵)C(O)NR⁵R⁶;

R⁴ is H, halo or alkyl;

R⁵ is H or alkyl;

R⁶ is selected from the group consisting of H, alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF₃, OCF₃, CN, —OR⁵, —NR⁵R¹⁰, —N(R⁵) (tertiarybutoxycarbonyl), —(CR⁴R⁵)_nOR⁵, —C(O)₂alkyl(C₂-C₆), —C(O)R⁵, —C(O)NR⁵R¹⁰, —SO₃H, —SR¹⁰, —S(O)₂R⁷, —S(O)₂NR⁵R¹⁰, —N(R⁵)S(O)₂R⁷, —N(R⁵)C(O)R⁷ and —N(R⁵)C(O)NR⁵R¹⁰ with the proviso that said arylalkyl is not substituted by the —C(O)₂alkyl(C₂-C₆);

R¹⁰ is selected from the group consisting of H, alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heteroaryl, and heteroarylalkyl, wherein each of said alkyl, aryl, arylalkyl, cycloalkyl, heterocyclyl, heteroaryl, and heteroarylalkyl can be unsubstituted or optionally substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF₃, OCF₃, CN, —OR⁵, —NR⁴R⁵, —N(R⁵) (tertiarybutoxycarbonyl), —(OR⁴R⁵)_nOR⁵, —C(O)₂R⁵, —C(O)N R⁴R⁵, —C(O)R⁵, —SO₃H, —SR⁵, —S(O)₂R⁷, —S(O)₂NR⁴R⁵, —N(R⁵)S(O)₂R⁷, —N(R⁵)C(O)R⁷ and —N(R⁵)C(O)NR⁴R⁵;

or optionally (i) R⁵ and R¹⁰ in the moiety —NR⁵R¹⁰, or (ii) R⁵ and R⁶ in the moiety —NR⁵R⁶, may be joined together to form a heterocyclyl moiety, with each of said heterocyclyl moiety being unsubstituted or optionally independently being substituted with one or more R⁹ groups;

R⁷ is selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, arylalkyl and heteroarylalkyl, wherein each of said alkyl, cycloalkyl, heteroarylalkyl, aryl, heteroaryl and arylalkyl can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different, each moiety being independently selected from the group consisting of halogen, alkyl, aryl, cycloalkyl, CF₃, OCF₃, CN, —OR⁵, —NR⁵R¹⁰, —CH₂OR⁵, —C(O)₂R⁵, —C(O)NR⁵R¹⁰, —C(O)R⁵, —SR¹⁰, —S(O)₂R¹⁰, —S(O)₂NR⁵R¹⁰, —N(R⁵)S(O)₂R¹⁰, —N(R⁵)C(O)R¹⁰ and —N(R⁵)C(O)NR⁵R¹⁰;

R⁸ is selected from the group consisting of R⁶, —C(O)NR⁵R¹⁰, —S(O)₂NR⁵R¹⁰, —C(O)R⁷and —S(O)₂R⁷;

R⁹ is selected from the group consisting of halogen, CN, —NR⁵R¹⁰, —C(O)₂R⁶, —C(O)NR⁵R¹⁰, —OR⁶, —SR⁶, —S(O)₂R⁷, —S(O)₂NR⁵R¹⁰, —N(R⁵)S(O)₂R⁷, —N(R⁵)C(O)R⁷and —N(R⁵)C(O)NR⁵R¹⁰;

m is 0 to 4, and

n is 1 to 4,