US 7,514,105 B2
	Bioavailability/bioefficacy enhancing activity of Cuminum cyminum and extracts and fractions thereof
Ghulam Nabi Qazi, Jammu (India); Kasturi Lal Bedi, Jammu (India); Rakesh Kamal Johri, Jammu (India); Manoj Kumar Tikoo, Jammu (India); Ashok Kumar Tikoo, Jammu (India); Subhash Chander Sharma, Jammu (India); Sheikh Tasaduq Abdullah, Jammu (India); Om Parkash Suri, Jammu (India); Bishan Datt Gupta, Jammu (India); Krishan Avtar Suri, Jammu (India); Naresh Kumar Satti, Jammu (India); Ravi Kant Khajuria, Jammu (India); Surjit Singh, Jammu (India); Anamika Khajuria, Jammu (India); and Bal Krishan Kapahi, Jammu (India)
Assigned to Council of Scientific and Industrial Research, New Delhi (India)
Filed on Feb. 23, 2006, as Appl. No. 11/360,653.
Application 11/360653 is a division of application No. 10/386395, filed on Mar. 11, 2003, granted, now 7,070,814.
Claims priority of provisional application 60/363460, filed on Mar. 12, 2002.
Prior Publication US 2006/0141080 A1, Jun. 29, 2006
Int. Cl. A61K 36/00 (2006.01); A61K 36/752 (2006.01)

U.S. Cl. 424—725  [424/736; 424/776]

2 Claims

1. A process for the preparation of a bioactive fraction from the plant Cuminum cyminum, said process comprising the steps of: (a) extracting crushed plant material Cuminum cyminum with water or 50% aqueous alcoholic solvent at a temperature range of 95-100° C. to obtain an aqueous extract or aqueous alcoholic extract respectively, (b) extracting a portion of the aqueous extract of step (a) with n-butanol (n-BuOH), separating the n-butanol layer and an aqueous layer, (c) evaporating, and freeze drying the aqueous layer step (b) to obtain fraction 2.