| US 7,351,566 B2 | ||
| 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor | ||
| Rachel E. Meyers, Newton, Mass. (US); Joseph M. Carroll, Cambridge, Mass. (US); William James Cook, Hanover, N.H. (US); Rosana Kapeller-Libermann, Chestnut Hill, Mass. (US); Nadine S. Weich, Brookline, Mass. (US); and Rajasekhar Bandaru, Watertown, Mass. (US) | ||
| Assigned to Millennium Pharmaceuticals, Inc., Cambridge, Mass. (US) | ||
| Filed on May 05, 2006, as Appl. No. 11/429,599. | ||
| Application 11/429599 is a division of application No. 10/391364, filed on Mar. 18, 2003, granted, now 7,094,587. | ||
| Application 10/391364 is a continuation in part of application No. 09/950370, filed on Sep. 10, 2001, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 10/294039, filed on Nov. 13, 2002, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 10/266035, filed on Oct. 07, 2002, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 09/717926, filed on Nov. 21, 2000, granted, now 6,569,657. | ||
| Application 10/391364 is a continuation in part of application No. 10/268036, filed on Oct. 09, 2002, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 09/922138, filed on Aug. 03, 2001, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 09/945327, filed on Aug. 31, 2001, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 10/163316, filed on Jun. 05, 2002, abandoned. | ||
| Application 10/391364 is a continuation in part of application No. 10/103377, filed on Mar. 21, 2002, abandoned. | ||
| Claims priority of provisional application 60/338587, filed on Nov. 13, 2001. | ||
| Claims priority of provisional application 60/328198, filed on Oct. 09, 2001. | ||
| Claims priority of provisional application 60/327820, filed on Oct. 09, 2001. | ||
| Claims priority of provisional application 60/297863, filed on Jun. 13, 2001. | ||
| Claims priority of provisional application 60/278347, filed on Mar. 23, 2001. | ||
| Claims priority of provisional application 60/231084, filed on Sep. 08, 2000. | ||
| Claims priority of provisional application 60/229299, filed on Sep. 01, 2000. | ||
| Claims priority of provisional application 60/229425, filed on Aug. 31, 2000. | ||
| Claims priority of provisional application 60/214707, filed on Jun. 27, 2000. | ||
| Prior Publication US 2006/0240464 A1, Oct. 26, 2006 | ||
| Int. Cl. C12N 9/12 (2006.01); C12N 5/00 (2006.01); C07H 21/04 (2006.01) | ||
| U.S. Cl. 435—194 [435/252.3; 435/252.33; 435/325; 435/254.1; 435/302.1; 536/23.2] | 14 Claims |
| 1. An isolated nucleic acid selected from the group consisting of:
a) a nucleic acid comprising the nucleotide sequence of SEQ ID NO:41 or SEQ ID NO:43;
b) a nucleic acid which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:42;
c) a nucleic acid comprising a nucleotide sequence which is at least 95% identical to the nucleotide sequence of SEQ ID NO:41
or SEQ ID NO:43, wherein the nucleotide sequence encodes a polypeptide which has calcium/calmodulin-dependent protein kinase
kinase alpha activity; and
d) a nucleic acid which encodes a polypeptide comprising an amino acid sequence which is at least 95% identical to the amino
acid sequence of SEQ ID NO:42, wherein the polypeptide has calcium/calmodulin-dependent protein kinase kinase alpha activity.
|