| US 7,511,094 B2 | ||
| Water-soluble polymer alkanals | ||
| Antoni Kozlowski, Huntsville, Ala. (US) | ||
| Assigned to Nektar Therapeutics AL, Corporation, Huntsville, Ala. (US) | ||
| Filed on Mar. 13, 2006, as Appl. No. 11/375,698. | ||
| Application 11/375698 is a continuation of application No. 10/659734, filed on Sep. 09, 2003, granted, now 7,157,546. | ||
| Claims priority of provisional application 60/456580, filed on Mar. 19, 2003. | ||
| Claims priority of provisional application 60/409251, filed on Sep. 09, 2002. | ||
| Prior Publication US 2006/0194940 A1, Aug. 31, 2006 | ||
| Int. Cl. C08G 63/48 (2006.01); C08G 63/91 (2006.01); C08G 10/00 (2006.01); C08G 12/00 (2006.01) | ||
| U.S. Cl. 525—50 [525/54.2; 525/54.3; 528/230; 528/491; 530/391.9; 530/406; 568/497] | 40 Claims |
1. A polymer having the structure:
 POLY is a water-soluble polymer segment;
X′ is a linker moiety,
z′ is an integer from 3 to about 21;
R1, in each occurrence, is independently H or an organic radical selected from the group consisting of alkyl, substituted alkyl,
alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, and substituted aryl;
R2, in each occurrence, is independently H or an organic radical selected from the group consisting of alkyl, substituted alkyl,
alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, and substituted aryl,
Wa and Wb are each independently O or S, and
R3 and R4 are each independently H, or an organic radical selected from the group consisting of methyl, ethyl, isopropyl, benzyl, 1,1,1-trichloroethyl,
and nitrobenzyl, or when taken together, are —(CH2)2— or —(CH2)3—, forming a 5 or 6 membered ring when considered together with Wa, C1, and Wb.
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