| US 7,511,039 B2 | ||
| β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins | ||
| Michael Kahn, Kirkland, Wash. (US); Cyprian O. Ogbu, Durham, N.C. (US); Masakatsu Eguchi, Seattle, Wash. (US); Hwa-Ok Kim, Lexington, Mass. (US); and Patrick D. Boatman, Jr., San Diego, Calif. (US) | ||
| Assigned to Myriad Genetics, Inc., Salt Lake City, Utah (US) | ||
| Filed on Jun. 07, 2006, as Appl. No. 11/448,412. | ||
| Application 09/561107 is a division of application No. 09/009665, filed on Jan. 20, 1998, granted, now 6,245,764. | ||
| Application 11/448412 is a continuation of application No. 10/745471, filed on Dec. 22, 2003, granted, now 7,125,872. | ||
| Application 10/745471 is a continuation of application No. 09/561107, filed on Apr. 28, 2000, granted, now 6,699,869. | ||
| Application 09/009665 is a continuation of application No. 08/725073, filed on Oct. 02, 1996, abandoned. | ||
| Application 08/725073 is a continuation in part of application No. 08/624690, filed on Mar. 25, 1996, abandoned. | ||
| Application 08/624690 is a continuation in part of application No. 08/549006, filed on Oct. 27, 1995, abandoned. | ||
| Application 08/549006 is a continuation in part of application No. 08/410518, filed on Mar. 24, 1995, abandoned. | ||
| Prior Publication US 2006/0276408 A1, Dec. 07, 2006 | ||
| Int. Cl. A01N 43/58 (2006.01) | ||
| U.S. Cl. 514—248 [514/19; 514/221; 514/405; 548/356] | 28 Claims |
1. A compound having either a first structure:
 or a pharmaceutically acceptable salt thereof,
wherein R1, R2 and R3 are independently selected from amino acid side chain moieties and derivatives thereof; A is selected from —(CH2)1-2O— and —(CH2)1-2S—; B is N; C is selected from —C(═O)—, —(CH2)1-3—, —O—, —S—, —O—(CH2)1-2— and —S(CH2)1-2; Y and Z represent the remainder of the molecule; and any two adjacent CH groups of the bicyclic ring may form a double bond,
or a second structure:
 or a pharmaceutically acceptable salt thereof,
wherein X has the structure —(CH2)n—, where “n” is an integer of 0-3, wherein any two adjacent CH groups of the bicyclic ring may form a double bond, wherein
R1, R2, R3, C, Y, and Z are as defined above, except with the proviso that when X has the structure —(CH2)0-2—, C has the structure —(CH2)1-2—, and R2 is H, then R1 is not H.
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