| US 7,510,882 B2 | ||
| Method and biosensor for analysis | ||
| Inger Vikholm, Tampere (Finland); and Janusz Sadowski, Tampere (Finland) | ||
| Assigned to Bionavis Ltd., Helsinki (Finland) | ||
| Filed on Apr. 16, 2007, as Appl. No. 11/785,238. | ||
| Application 11/785238 is a division of application No. 10/164652, filed on Jun. 10, 2002, granted, now 7,332,327. | ||
| Claims priority of application No. 20011877 (FI), filed on Sep. 24, 2001. | ||
| Prior Publication US 2007/0254382 A1, Nov. 01, 2007 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. G01N 33/543 (2006.01); G01N 33/551 (2006.01); G01N 33/552 (2006.01); G01N 33/553 (2006.01) | ||
| U.S. Cl. 436—518 [310/313 R; 310/340; 385/12; 385/129; 385/130; 422/57; 422/82.11; 435/287.2; 435/287.9; 435/288.7; 435/808; 435/962; 436/512; 436/164; 436/524; 436/525; 436/527; 436/810] | 18 Claims |
| 1. A method for analysis, comprising:
binding analytes (4) in a sample to biomolecules (3) attached to a solid surface of a substrate (1); and
detecting the analytes bound to the biomolecules; wherein:
the biomolecules (3) are attached directly in an oriented manner to the substrate together with biomolecule-repellent molecules (5); and
the biomolecule-repellent molecules are covalently attached to the substrate through functional groups and are self-assembled
on the surface to cover the surface between the biomolecules (3) to prevent non-specific binding of analytes (4) and other biomolecules.
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