US 7,510,863 B2
Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making
Siba K. Samal, College Park, Md. (US); and Govindarajan Dhanasekaran, Silver Spring, Md. (US)
Assigned to University of Maryland, College Park, College Park, Md. (US)
Filed on Jun. 16, 2004, as Appl. No. 10/868,381.
Application 10/868381 is a continuation in part of application No. PCT/US03/38123, filed on Dec. 02, 2003.
Claims priority of provisional application 60/430301, filed on Dec. 02, 2002.
Prior Publication US 2005/0037479 A1, Feb. 17, 2005
Int. Cl. C12N 7/00 (2006.01); C12N 7/04 (2006.01); A61K 39/155 (2006.01)
U.S. Cl. 435—235.1  [435/236; 424/211.1] 2 Claims
 
1. A live-attenuated avian pneumovirus containing one or more attenuating mutations in the F protein cleavage site, wherein the sequence of the mutated F protein cleavage site is Arg-Gln-Gly-Arg (SEQ ID NO:20).