| US 7,348,003 B2 | ||
| Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors | ||
| Theodora W. Salcedo, East Syracuse, N.Y. (US); Steven M. Ruben, Brookeville, Md. (US); Craig A. Rosen, Laytonsville, Md. (US); Vivian R. Albert, Rockville, Md. (US); Claire Dobson, Cambridge (United Kingdom); and Tristan Vaughan, Cambridge (United Kingdom) | ||
| Assigned to Human Genome Sciences, Inc., Rockville, Md. (US) | ||
| Filed on Nov. 12, 2004, as Appl. No. 10/986,047. | ||
| Application 10/986047 is a continuation in part of application No. PCT/US03/25457, filed on Aug. 15, 2003. | ||
| Application PCT/US03/25457 is a continuation in part of application No. 10/139785, filed on May 07, 2002, granted, now 7,064,189, filed on Jun. 20, 2006. | ||
| Claims priority of provisional application 60/608362, filed on Sep. 10, 2004. | ||
| Claims priority of provisional application 60/425730, filed on Nov. 13, 2002. | ||
| Claims priority of provisional application 60/403382, filed on Aug. 15, 2002. | ||
| Claims priority of provisional application 60/468050, filed on May 06, 2003. | ||
| Claims priority of provisional application 60/293473, filed on May 25, 2001. | ||
| Claims priority of provisional application 60/294981, filed on Jun. 04, 2001. | ||
| Claims priority of provisional application 60/309176, filed on Aug. 02, 2001. | ||
| Claims priority of provisional application 60/323807, filed on Sep. 21, 2001. | ||
| Claims priority of provisional application 60/327364, filed on Oct. 09, 2001. | ||
| Claims priority of provisional application 60/331044, filed on Nov. 07, 2001. | ||
| Claims priority of provisional application 60/331310, filed on Nov. 14, 2001. | ||
| Claims priority of provisional application 60/341237, filed on Dec. 20, 2001. | ||
| Claims priority of provisional application 60/369860, filed on Apr. 05, 2002. | ||
| Prior Publication US 2005/0129699 A1, Jun. 16, 2005 | ||
| Int. Cl. A61K 39/395 (2006.01); G01N 33/53 (2006.01); C12P 21/04 (2006.01); C12P 21/08 (2006.01); C07K 16/00 (2006.01); C07H 21/04 (2006.01) | ||
| U.S. Cl. 424—133.1 [424/139.1; 424/142.1; 424/143.1; 424/155.1; 435/69.6; 435/70.21; 530/387.3; 530/387.9; 530/388.1; 530/388.15; 530/388.22; 530/388.8] | 43 Claims |
| 1. A method of treating a TR4 expressing cancer comprising administering to an animal an isolated antibody or fragment thereof
comprising the amino acid sequence selected from the group consisting of:
(a) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:42;
(b) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:43; and
(c) an amino acid sequence that is at least 95% identical to the VH and VL domains of SEQ ID NO:47; wherein said antibody or fragment thereof immunospecifically binds a TR4 protein selected from the group consisting of:
(i) a polypeptide having the amino acid sequence of any one of amino acid residues 1 to 468 of SEQ ID NO:1, amino acid residues
24 to 468 of SEQ ID NO:1, amino acid residues 24 to 238 of SEQ ID NO:1, and amino acid residues 109 to 240 of SEQ ID NO:1;
(ii) a multimer of the polypeptide of (i);
(iii) the polypeptide of (i) expressed on the surface of a cell; and
(iv) the multimer of (ii) expressed on the surface of a cell; or a composition containing said antibody or fragment thereof.
|