	US 7,507,707 B2
	Methods of inducing ovulation using a non-polypeptide camp level modulator
Stephen Palmer, Plympton, Mass. (US); Mark Tepper, Canton, Mass. (US); Sean McKenna, Ducksberry, Mass. (US); Michael C. MacNamee, Bourn (United Kingdom); and Aliza Eshkol, La Rippe (Switzerland)
Assigned to Laboratoires Serono SA, Coinsins, Vaud (Switzerland)
Appl. No. 10/498,639 PCT Filed Dec. 14, 2001, PCT No. PCT/EP01/14730 § 371(c)(1), (2), (4) Date Feb. 18, 2005, PCT Pub. No. WO03/051344, PCT Pub. Date Jun. 26, 2003.
Prior Publication US 2005/0148501 A1, Jul. 07, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/00 (2006.01)

U.S. Cl. 514—2 [436/65]

15 Claims

1. A method of ovulation induction in a female host comprising administering to a female host in need thereof a non-polypeptide cAMP level modulator, wherein said non-polypeptide cAMP level modulator is an inhibitor of a phosphodiesterase 4 isoform selected from the group consisting of:

Theophylline (1,3-dimethylxanthine), isobutylmethylxanthine, AH-21-132 (6-(4-acetamidophenyl)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo(c)(1,6)-naphthyridine-bis(hydrogen maleate), Org-30029 (N′-hydroxy-5,6-dimethoxy-benzothiophene-2-carboximidamide hydrochloride), Org-20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)thiazole-2-carboximidamide), Org-9731 (4-fluoro-N-hydroxy-5,6-dimethoxybenzo(b)thiophene-2-carboximidamide methanesulfonate), Zardaverine (6-[4-(difluoromethoxy)-3-methoxy-phenyl]-2H-pyridazin-3-one), vinpocetine (apovincaminic acid ethyl ester), EHNA (MEP-1) (9-(2-hydroxy-3-nonyl)adenine), Milrinone (6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile), Siguazodan (3-cyano-2-methyl-1-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine), Zaprinast (3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0]nona-1,3,6-trien-5-one), SK+F 96231 (2-(2-propoxyphenyl)-3,7-dihydropurin-6-one), Tolafentrine ((−)-4′-(cis-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo(c)(1,6)naphthyridin-6-yl)-p-toluenesulfonanilide), Filaminast ([1-(3-cyclopentyloxy-4-methoxy-phenyl)ethylideneamino]carbamate), Cis-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexane-1-carboxylic acid; 2-(4-(6,7-Diethoxy-2,3-bis(hydroxymethyl)naphthalen-1-yl)pyridin-2-yl)-4-(3-pyridyl)pthalazin-1 (2H)-one hydrochloride; and 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine.