US 7,507,483 B2
	Enhanced bonding layers on native oxide surfaces
Jeffrey Schwartz, 55 Locust La., Princeton, N.J. 08540 (US); Michael J. Avaltroni, 152 Dalton Ave., Staten Island, N.Y. 10306 (US); Michael D. Carolus, 217B Halsey St., Princeton, N.J. 08540 (US); Eric L. Hanson, 805 Millstone Apts., Princeton, N.J. 08540 (US); Jean E. Schwarzbauer, 193 Moore St., Princeton, N.J. 08540 (US); Kim S. Midwood, 53 Stanworth La., Princeton, N.J. 08540 (US); and Michael P. Danahy, 223A King St., Princeton, N.J. 08540 (US)
Filed on Apr. 01, 2003, as Appl. No. 10/405,557.
Application 10/405557 is a continuation in part of application No. 10/179743, filed on Jun. 24, 2002.
Application 10/179743 is a continuation in part of application No. 09/668080, filed on Sep. 22, 2000, granted, now 6,645,644.
Claims priority of provisional application 60/300144, filed on Jun. 22, 2001.
Claims priority of provisional application 60/155398, filed on Sep. 22, 1999.
Prior Publication US 2004/0023048 A1, Feb. 05, 2004
Int. Cl. B32B 15/04 (2006.01); B32B 9/00 (2006.01)

U.S. Cl. 428—624  [428/629; 428/639; 428/660; 428/472.3; 428/704; 623/23.76; 148/254]

15 Claims

1. An implantable device comprising a metal, metal alloy, metalloid, polymeric or ceramic surface with an oxide overlayer, and a phosphonic acid coating layer covalently bonded to the oxide overlayer, wherein said coating layer is formed by coating said oxide overlayer with a self-assembled layer of organophosphonic acid molecules comprising organic ligands containing from about 2 to 20 carbon atoms and heating said coated oxide overlayer so that the organophosphonic acid groups react with said oxide overlayer and bond said self-assembled layer thereto, and the phosphonic acid organic ligands are functionalized at the omega carbons.