	US 7,345,178 B2
	Sirtuin modulating compounds
Joseph J. Nunes, Andover, Mass. (US); Jill Milne, Brookline, Mass. (US); Jean Bemis, Arlington, Mass. (US); Roger Xie, Southborough, Mass. (US); Chi B. Vu, Arlington, Mass. (US); Pui Yee Ng, Boston, Mass. (US); and Jeremy S. Disch, Natick, Mass. (US)
Assigned to Sirtris Pharmaceuticals, Inc., Cambridge, Mass. (US)
Filed on Aug. 04, 2006, as Appl. No. 11/499,919.
Claims priority of provisional application 60/705612, filed on Aug. 04, 2005.
Claims priority of provisional application 60/741783, filed on Dec. 02, 2005.
Claims priority of provisional application 60/779370, filed on Mar. 03, 2006.
Claims priority of provisional application 60/792276, filed on Apr. 14, 2006.
Prior Publication US 2007/0043050 A1, Feb. 22, 2007
Int. Cl. C07D 513/00 (2006.01); A01N 43/78 (2006.01)

U.S. Cl. 548—154 [514/366]

30 Claims

1. A compound of the formula:

or a salt thereof, wherein

R¹⁹is

wherein:

each Z₁₀, Z₁₁, Z₁₂and Z₁₃is independently selected from CR²⁰or CR₁′;

wherein:

zero to one R²⁰is a solubilizing group; and

zero to one R₁′ is an optionally substituted C₁-C₃straight or branched alkyl;

each R²⁰is independently selected from H or a solubilizing group;

R²¹is —NR₁′—C(O)—;

each R₁′ is independently selected from H or optionally substituted C₁-C₃straight or branched alkyl; and

R³¹is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that R³¹is not 4-cyanophenyl or