	US 7,504,560 B2
	Vaccines expressed in plants
Charles Joel Arntzen, The Woodlands, Tex. (US); and Dominic Man-Kit Lam, The Woodlands, Tex. (US)
Assigned to Prodigene, Inc., College Station, Tex. (US)
Filed on May 12, 2005, as Appl. No. 11/127,965.
Application 08/479742 is a division of application No. 08/026393, filed on Mar. 04, 1993, granted, now 5,612,487, filed on Mar. 18, 1997.
Application 11/127965 is a continuation of application No. 09/676734, filed on Sep. 29, 2000, abandoned.
Application 09/676734 is a continuation of application No. 09/111330, filed on Jul. 07, 1998, granted, now 6,136,320, filed on Oct. 24, 2000.
Application 09/111330 is a continuation of application No. 08/479742, filed on Jun. 07, 1995, granted, now 5,914,123, filed on Jun. 22, 1999.
Application 08/026393 is a continuation in part of application No. PCT/US94/02332, filed on Mar. 04, 1994.
Application 08/026393 is a continuation in part of application No. 07/750049, filed on Aug. 26, 1991, abandoned.
Application 09/676734 is a continuation in part of application No. 08/156508, filed on Nov. 23, 1993, granted, now 5,484,719, filed on Jan. 16, 1996.
Prior Publication US 2005/0232949 A1, Oct. 20, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. A01H 5/00 (2006.01); A61K 39/12 (2006.01); A61K 39/29 (2006.01); C12N 15/82 (2006.01)

U.S. Cl. 800—298 [800/288; 800/317.4; 424/93.21; 424/186.1; 424/189.1; 424/223.1; 424/227.1; 424/439; 424/442]

9 Claims

1. A transgenic edible plant comprising:

a nucleotide construct encoding an immunogen of a recombinant animal viral antigen protein, said construct including one or more of the following to regulate expression of said protein:

a promoter that preferentially targets expression to an edible tissue of the plant;

a 5′ non translated leader sequence, and

wherein said recombinant animal viral antigen protein is expressed in said plant at a level sufficient to induce an immune response when said plant is orally administered to an animal.