| US 7,504,113 B2 | ||
| Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions | ||
| Riitta Lassila, Espoo (Finland); Petri Kovanen, Espoo (Finland); and Ken Lindstedt, Helsinki (Finland) | ||
| Assigned to Jenny Ja Antti Wihurin Rahasto, Helsinki (Finland) | ||
| Filed on Jul. 17, 2007, as Appl. No. 11/826,668. | ||
| Application 10/418095 is a division of application No. 09/230097, abandoned, previously published as PCT/FI98/00925, filed on Nov. 25, 1998. | ||
| Application 11/826668 is a continuation of application No. 10/418095, filed on Apr. 18, 2003, granted, now 7,314,860. | ||
| Claims priority of application No. 974321 (FI), filed on Nov. 25, 1997. | ||
| Prior Publication US 2008/0014239 A1, Jan. 17, 2008 | ||
| Int. Cl. A61F 2/04 (2006.01); A61K 31/726 (2006.01); A61P 7/02 (2006.01) | ||
| U.S. Cl. 424—422 [514/8; 514/56; 536/21] | 18 Claims |
| 1. A heparin-like compound for inhibiting collagen induced platelet aggregation associated with vascular or microvascular
injuries and/or interventions, wherein:
the heparin-like compound comprises several heparin glycosaminoglycan molecules connected to a globular core molecule;
the heparin glycosaminoglycan molecules are multiple heparin molecules comprising several end-to-side connected glycosaminoglycan
units or several end-to-side and end-to-end connected glycosaminoglycan units; and
the heparin-like compound provides inhibition of collagen-induced platelet aggregation with preserved platelet adhesion on
collagen in flowing blood.
|