US 7,501,513 B2
Immunosuppressive effects of pteridine derivatives
Mark Jozef Albert Waer, Heverlee (Belgium); Piet André Maurits Maria Herdewijn, Rotselaar/Wezemaal (Belgium); Wolfgang Eugen Pfleiderer, Constance (Germany); Arnaud Didier Marie Marchand, Heverlee (Belgium); and Steven Cesar Alfons De Jonghe, Brussels (Belgium)
Assigned to 4 AZA Bioscience NV, Leuven (Belgium)
Appl. No. 10/595,126
PCT Filed Aug. 27, 2004, PCT No. PCT/BE2004/000124
§ 371(c)(1), (2), (4) Date Feb. 27, 2006,
PCT Pub. No. WO2005/021003, PCT Pub. Date Mar. 10, 2005.
Application 10/595126 is a continuation in part of application No. 10/651604, filed on Aug. 29, 2003, granted, now 7,276,506.
Claims priority of application No. 0408955.3 (GB), filed on Apr. 22, 2004.
Prior Publication US 2006/0287314 A1, Dec. 21, 2006
Int. Cl. C07D 475/08 (2006.01)
U.S. Cl. 544—258 6 Claims
OG exemplary drawing
 
1. A pteridine derivative selected from the group consisting of:
2-amino-4-morpholino-6-(4-acetanilide)pteridine,
2-amino-4-morpholino-6-(3-acetanilide)pteridine,
2-amino-4-morpholino-6-(4-aminophenyl)pteridine,
2-amino-4-morpholino-6-(3-aminophenyl)pteridine,
2-amino-4-morpholino-6-(4-benzoylaminophenyl)pteridine,
2-amino-4-morpholino-6-(4-phenoxyacetylaminophenyl)pteridine,
2-amino-4-morpholino-6-(4-propionylaminophenyl)pteridine,
2-amino-4-morpholino-6-(4-furoylaminophenyl)pteridine,
2-amino-4-morpholino-6-(4-cyclohexanoylaminophenyl)pteridine,
2-amino-4-morpholino-6-[4-(4-chlorobenzoyl)aminophenyl]pteridine,
2-amino-4-morpholino-6-(4-benzyloxyacetylaminophenyl)pteridine,
2-amino-4-morpholino-6-(4-isonicotinoylaminophenyl)pteridine;
2-amino-4-morpholino-6-(4-naphtoylaminophenyl)pteridine;
2-amino-4-morpholino-6-(4-methylsulfonylaminophenyl)pteridine;
2-amino-4-morpholino-6-(4-ethylsuccinylaminophenyl)pteridine;
2-amino-4-morpholino-6-[4-(4-methylbenzoate)aminophenyl)pteridine;
2-amino-4-morpholino-6-(3-benzoylaminophenyl)pteridine;
2-amino-4-morpholino-6-(3-benzensulfonylaminophenyl)pteridine,
2-amino-4-morpholino-6-(3-phenoxyacetylaminophenyl)pteridine;
2-amino-4-morpholino-6-(3-isonicotinoylaminophenyl)pteridine;
2-amino-4-morpholino-6-(3-cyclohexanoylaminophenyl)pteridine;
2-amino-4-morpholino-6-[3-(4-methylbenzoate)aminophenyl]pteridine;
2-amino-4-morpholino-6-(3-ethylsuccinylaminophenyl)pteridine;
2-amino-4-morpholino-6-(3-ethylmalonylaminophenyl)pteridine;
2-amino-4-morpholino-6-(3-benzyloxyacetylaminophenyl)pteridine,
2-amino-4-morpholino-6-(3-ethylsulfonylaminophenyl)pteridine,
2-amino-4-morpholino-6-[3-Boc-(L)-phenylalanine-aminophenyl]pteridine;
2-amino-4-morpholino-6-[3-Boc-(D)-phenylalanine-aminophenyl]pteridine;
2-amino-4-morpholino-6-[3-Boc-(L)-tryptophane-aminophenyl]pteridine;
2-amino-4-morpholino-6-[3-Boc-(D)-tryptophane-aminophenyl]pteridine,
2-amino-4-morpholino-6-(4-hydroxyphenyl)pteridine,
2,4-di-(thienyl-2-methylarnino)-6-(3,4-dimethoxy-phenyl)pteridine,
2-amino-4-morpholino-6-(4-benzyloxyphenyl)pteridine,
2-amino-4-morpholino-6-(4-(phenethyloxy)-phenyl)pteridine,
2-amino-4-morpholino-6-(4-phenoxy-butyronitrile)pteridine,
2-amino-4-morpholino-6-(4-propoxy-phenyl)pteridine,
2-amino-4-morpholino-6-(4-phenoxy-butyric acid ethyl ester)pteridine,
2-amino-4-morpholino-6-(4-phenoxy-acetic acid ethyl ester)pteridine,
2-amino-4-morpholino-6-(4-(2-methoxyethoxy)-phenyl)pteridine,
2-amino-4-morpholino-6-(4-butoxy-phenyl)-pteridine,
2-amino-4-(diethanolamino)-6-[[3,4-(dimethoxyphenyl)]pteridine,
2-amino-4-(benzylamino)-6-[[3,4-(dimethoxyphenyl)]pteridine;
2-amino-4-(phenylethylamino)-6-[[3,4-(dimethoxyphenyl)]pteridine,
2-amino-4-(2-thienylmethylamino)-6-[[3,4-(dimethoxyphenyl)]pteridine,
2-amino-4-thiomorpholine-6-[[3,4-(dimethoxyphenyl)]pteridine.