| US 7,501,449 B2 | ||
| 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | ||
| Laurent DuBois, Le Pleassis-Robinson (France); Yannick Evanno, Bullion (France); Christian Maloizel, Meudon (France); and Mireille Sevrin, Paris (France) | ||
| Assigned to Sanofi-Aventis, Paris (France) | ||
| Filed on Oct. 13, 2006, as Appl. No. 11/549,293. | ||
| Application 11/549293 is a continuation of application No. PCT/FR2005/001154, filed on May 10, 2005. | ||
| Claims priority of application No. 04 05055 (FR), filed on May 11, 2004. | ||
| Prior Publication US 2007/0105932 A1, May 10, 2007 | ||
| Int. Cl. A61K 31/416 (2006.01); C07D 231/54 (2006.01) | ||
| U.S. Cl. 514—407 [548/356.1; 548/358.1; 548/359.1; 514/403; 514/406] | 7 Claims |
1. A compound corresponding to the formula (I)
 W represents an oxygen or sulphur atom;
X1, X2, X3 and X4 each represent, independently of one another, a hydrogen or halogen atom or a cyano, C1-C6-alkyl, C1-C6-fluoroalkyl, C1-C6-alkoxy or C1-C6 fluoroalkoxy group;
Y is in the (N2) or (N3) position;
when Y is in the (N2) position, Y represents a C1-C6-alkyl, C1-C6-fluoroalkyl, aryl or heteroaryl group;
when Y is in the (N3) position, Y represents an aryl or heteroaryl group;
the aryl or heteroaryl groups optionally being substituted by one or more atoms or groups selected from halogen atoms and
C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkyl-S(O)—, C1-C6-alkyl-S(O)2— and C1-C6-fluoroalkyl groups;
the bond in the C4-C5 position is a double or single bond;
R1 and R2 each represent, independently of one another, an aryl, benzyl or C1-C6-alkyl group; or else R1 and R2 form, with the nitrogen atom to which they are attached, a heterocycle optionally substituted by one or more C1-C6-alkyl or benzyl groups;
in the form of the base or of an addition salt with an acid, and in the hydrate or solvate form.
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