| US 7,501,422 B2 | ||
| Prolinamide-tetrazole derivatives as NK3 receptor antagonists | ||
| Bo Han, Shanghai (China); Henner Knust, Rheinfelden (Germany); Matthias Nettekoven, Grenzach-Wyhlen (Germany); Hasane Ratni, Habsheim (France); and Xihan Wu, Shanghai (China) | ||
| Assigned to Hoffmann-La Roche Inc., Nutley, N.J. (US) | ||
| Filed on May 30, 2008, as Appl. No. 12/129,720. | ||
| Claims priority of application No. 07109783 (EP), filed on Jun. 07, 2007. | ||
| Prior Publication US 2008/0306089 A1, Dec. 11, 2008 | ||
| Int. Cl. A61K 31/496 (2006.01); C07D 403/04 (2006.01) | ||
| U.S. Cl. 514—254.05 [544/366] | 7 Claims |
1. A compound of formula I
 R1 is cycloalkyl or is phenyl unsubstituted or substituted by one or two halogen atoms;
R2 is hydrogen or halogen;
R3 is hydrogen, CN, lower alkoxy, lower alkyl or halogen; and
n is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof.
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