US 7,501,413 B2
Dicarboxamide derivatives
Markus Boehringer, Moehlin (Switzerland); Katrin Groebke Zbinden, Basel (Switzerland); Wolfgang Haap, Loerrach (Germany); Hans Hilpert, Muenchenstein (Switzerland); Jacques Himber, Guebwiller (France); Roland Humm, Auggen (Germany); Hans Iding, Rheinfelden (Germany); Dietmar Knopp, Basel (Switzerland); Narendra Panday, Basel (Switzerland); Fabienne Ricklin, Hombourg (France); and Christoph Martin Stahl, Freiburg (Germany)
Assigned to Hoffmann-La Roche Inc., Nutley, N.J. (US)
Filed on Oct. 31, 2005, as Appl. No. 11/263,497.
Claims priority of application No. 04105465 (EP), filed on Nov. 03, 2004; and application No. 05100132 (EP), filed on Jan. 12, 2005.
Prior Publication US 2006/0106016 A1, May 18, 2006
Int. Cl. C07D 413/02 (2006.01); C07D 401/02 (2006.01); A61K 31/44 (2006.01)
U.S. Cl. 514—235.2  [514/252.1; 514/278; 514/332; 514/349; 544/124; 544/405; 546/15; 546/255; 546/308] 42 Claims
 
1. A compound of formula (I)

OG Complex Work Unit Drawing
wherein
A is —CONH— or —NHCO—;
B is optionally substituted phenyl, optionally substituted heteroaryl or optionally substituted heterocyclyl;
Rc is optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl, one or two carbon atoms of said aryl, heteroaryl or heterocyclyl ring optionally being replaced with a carbonyl group;
D is aryl optionally substituted by one, two or three halogen atoms independently selected from chlorine, fluorine and bromine or heteroaryl optionally substituted by one, two or three halogen atoms independently selected from chlorine, fluorine and bromine;

OG Complex Work Unit Drawing
R1 and R2 are independently from each other hydrogen, halogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7cycloalkyl C1-6 alkyl, amino, mono-substituted amino, di-substituted amino, hydroxy, C1-6 alkoxy, mono-substituted amino-C1-6 alkyl, di-substituted amino-C1-6 alkyl, hydroxyl C1-6 alkyl or
R1 and R2 together form

OG Complex Work Unit Drawing
R1 and R2 are bonded to each other to form optionally substituted heterocyclyl, together with the carbon atom to which R1 and R2 are attached;
R3 and R4 are independently from each other hydrogen, C1-6 alkyl, carboxyl, C1-6 alkoxycarbonyl, carbamoyl, mono- or di-substituted amino-carbonyl, optionally substituted heterocyclylcarbonyl, optionally substituted heteroarylcarbonyl, optionally substituted aryl carbonyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, hydroxyl C1-6 alkyl, halo C1-6 alkyl, cyano C1-6 alkyl, C1-6 alkoxy C1-6 alkyl, amino C1-6 alkyl, mono- or di-substituted amino-C1-6 alkyl, optionally substituted aryl C1-6 alkyl, optionally substituted heterocyclyl C1-6 alkyl, optionally substituted heteroaryl C1-6 alkyl, optionally substituted aryl C1-6 alkoxy C1-6 alkyl, optionally substituted heteroaryl C1-6 alkoxy C1-6 alkyl, optionally substituted heterocyclyl C1-6 alkoxy C1-6 alkyl or
R3 and R4 are bonded to each other to form C3-7 cycloalkyl, together with the carbon atom to which R3 and R4 are attached;
R5 and R6 are independently from each other hydrogen, C1-6 alkyl, cyano, C1-6 alkoxycarbonyl, C2-6 alkenyloxycarbonyl, C2-6 alkynyloxycarbonyl, hydroxyl C1-6 alkyl, C1-6 alkoxycarbonyl, carboxyl, mono- or di-C1-6 alkyl substituted amino-carbonyl, aminocarbonyl, optionally substituted heterocyclyl carbonyl, optionally substituted heteroaryl carbonyl or optionally substituted aryl carbonyl;
R11 and R12 are independently from each other hydrogen, C1-6 alkyl or C2-6 alkenyl;
or pharmaceutically acceptable salts thereof.